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EC number: 237-044-7 | CAS number: 13597-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 November 2017 - 13 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Version / remarks:
- July 2001
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The analysis was not performed in compliance with GLP principles, but according to the ISO 17025 standard.
- Type of method:
- other: Transformation/Dissolution Screening
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 25 µg/L
- Element analysed:
- Vanadium
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 6
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 41.5 µg/L
- Element analysed:
- Vanadium
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 8
- Details on results:
- The following observations were made from the test vessels at the nominal pH 6 with a loading of 100 mg/L test item:
- An average dissolved concentration of 25.0 ± 1.3 μg/L V was found at the 24 hours endpoint with a between-vessel coefficient of variation of 5 % (N = 3) which meets the <20 % quality criteria at the 24 hours endpoint. The within-vessel coefficients of variation meet the <10 % quality criteria for all test vessels. Based on the specific surface area of the test item powder (i.e. 50.7 m²/g), a vanadium release per surface of 0.0049 mg/m² was calculated at the 24 hours endpoint. Based on the vanadium content of the test item (1.61 % V) and the average dissolved vanadium concentration, a vanadium release of approximately 1.6 % could be calculated at the 24 hours endpoint
The following observations were made from the test vessels at the nominal pH 8 with a loading of 100 mg/L test item:
- An average dissolved concentration of 41.5 ± 0.6 μg/L V was found at the 24 hours endpoint with a between-vessel coefficient of variation of 2 % (N = 3) which meets the <20 % quality criteria at the 24 hours endpoint. The within-vessel coefficients of variation meet the <10 % quality criteria for all test vessels. Based on the specific surface area of the test item powder (i.e. 50.7 m²/g), a vanadium release per surface of 0.0082 mg/m² was calculated at the 24 hours endpoint. Based on the vanadium content of the test item (1.61 % V) and the average dissolved vanadium concentration, a vanadium release of approximately 2.6 % could be calculated at the 24 hours endpoint. - Conclusions:
- In a 24-hour screening study with a loading rate of 100 mg test item/L, an average vanadium concentration of 25.0 μg/L was measured at pH 6 and an average concentration of 41.5 μg/L was measured at pH 8.
- Executive summary:
Brouwers (2018) is a GLP compliant study following OECD guideline 29 and is considered to be reliable without restrictions (Klimisch 1). A 24-hour screening study was conducted with a loading rate of 100 mg/L, at pH 6 and pH 8. Vanadium concentrations were analysed using ICP-MS. The concentration of total organic carbon (TOC) in the medium was <1.0 mg/L C and below the required level of 2.0 mg/L C. This was confirmed by a total organic carbon (TOC) analysis of a 100 mL sample of the 0.2 μm filtered test medium.
For vanadium an average concentration of 25.0 μg/L was measured at pH 6. Based on the specific surface area of the test item, a release per surface of 0.0049 mg/m² V was calculated. Based on the vanadium content (1.61 % V) in the test item and the average dissolved vanadium concentrations in the test solutions, a vanadium release of 1.6 % was calculated as the 24 hours endpoint.
For vanadium an average concentration of 41.5 μg/L was measured at pH 8. Based on the specific surface area of the test item, a release per surface of 0.0082 mg/m² V was calculated. Based on the vanadium content (1.61 % V) in the test item and the average dissolved vanadium concentrations in the test solutions, a vanadium release of 2.6 % was calculated at the 24 hours endpoint. In conclusion, the screening study demonstrated that the highest release of vanadium from the test item occurs at pH 8.
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 December 2017 - 21 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Version / remarks:
- July 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The analysis was not conducted to GLP, but according to ISO 17025
- Type of method:
- other: Transformation/Dissolution Full test
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: IC21424
- Expiration date of the lot/batch: 23-05-2021
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, in the dark
- Stability under test conditions: Standard test conditions
FORM AS APPLIED IN THE TEST (if different from that of starting material) the test item as received did fulfil the <1 mm size requirements. Therefore, there was no need for further preparation of the test item.
Test item composition:
20.7 % Aluminium oxide [CAS: 1344-28-1]
64.9 % Magnesium oxide [CAS: 1309-48-4]
5.1 % Cerium dioxide [CAS: 1306-38-3]
1.0 % Diiron trioxide [CAS: 1309-37-1]
3.6 % Cerium Vanadium oxide [CAS: 13597-19-8]
1.7 % Magnesium Vanadium oxide [CAS: 13573-13-2]
1.0 % Calcium Vanadium Oxide [CAS: 14100-64-2]
2.0 % Water [CAS: 7732-18-5] - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 7.34 µg/L
- Element analysed:
- Vanadium
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- pH 8
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 5.13 µg/L
- Element analysed:
- Vanadium
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8
- Details on results:
- The following observations were made at pH 8:
An average dissolved vanadium concentration of 5.13 ± 0.26 μg/L V at the 7 day sampling point and 7.34 ± 0.30 μg/L V at the 28 day endpoint was measured with a between-vessel variation of 5 % (N = 3) and 4 % (N = 3) respectively, which met the <20 % quality criteria at the 7 and 28 days endpoints. The within-vessel coefficients of variation met the <10 % quality criteria for all test vessels at the 7 and 28 days endpoints. The dissolution of vanadium could be described by second order kinetic model which is showed in Figure 1b and the subsequent estimated equations.
Based on the average exposed surface area of the the test item (i.e. 50.7 m²/g), a vanadium release per surface of 0.10 mg/m² and 0.14 mg/m² was calculated at the 7 days and 28 days extraction endpoints, respectively.
Based on the average vanadium content in the test item (1.61 %) and the average dissolved vanadium concentrations in the test solution, a vanadium release of 32 % and 46 % was calculated at the 7 days and 28 days endpoints, respectively. - Conclusions:
- At a loading rate of 1 mg/L, at pH 8, the average dissolved vanadium concentrations were 5.13 and 7.34 μg/L after 7 and 28 days, respectively.
- Executive summary:
Brouwers (2018) is a GLP compliant study following OECD guideline 29 and is considered to be reliable without restrictions (Klimisch 1). The test item was tested at a loading rate of 1 mg/L, for 28 days at pH 8. The average dissolved vanadium concentrations were 5.13 and 7.34 μg/L after 7 and 28 days, respectively. Based on the average vanadium content of the test item (1.61%), a vanadium release of 32% and 46% was calculated after 7 and 28 days, respectively. Based on the average exposed surface area of the test item (50.7 m2/g) a vanadium release per surface area of 0.10 mg/m² and 0.14 mg/m² was calculated at 7 and 28 days, respectively.
Referenceopen allclose all
Table 1 24-hours Screening test at 100rpm ontest itemat a100mg/L loadingin a standard aqueous medium atpH 6. Data of measured dissolved vanadium concentrations, temperature, pH and dissolved oxygen concentration in test vessels.
(BLANK CORRECTED, if the blank value is higher than reporting limit, otherwise blank assumed as 0)
100 mg/L test item pH 6, 100 rpm |
µg/L V |
T (°C) |
pH |
DO (mg/L O2) |
|
Accredited reporting limit |
0.5 |
||||
Replica 1 |
Spl1 |
25.4 |
22.4 |
6.00 |
8.40 |
|
Spl2 |
25.4 |
|||
|
Spl3 |
25.4 |
|||
|
Xavg,1 |
25.4 |
|||
|
Swithin,1 |
0.0 |
|||
|
CVwithin,1(%) |
0 |
|||
Replica 2 |
Spl1 |
26.1 |
22.4 |
5.99 |
8.42 |
|
Spl2 |
26.1 |
|||
|
Spl3 |
26.1 |
|||
|
Xavg,2 |
26.1 |
|||
|
Swithin,2 |
0.0 |
|||
|
CVwithin,2(%) |
0 |
|||
Replica 3 |
Spl1 |
23.7 |
22.4 |
6.00 |
8.37 |
|
Spl2 |
23.5 |
|||
|
Spl3 |
23.5 |
|||
|
Xavg,3 |
23.6 |
|||
|
Swithin,3 |
0.1 |
|||
|
CVwithin,3(%) |
0 |
|||
Xavg |
25.0 |
|
|
|
|
Sbetween |
1.3 |
|
|
|
|
CVbetween(%) |
5 |
|
|
|
|
S |
1.1 |
|
|
|
|
CV |
5 |
|
|
|
xavg,vwithin vessel average of 3 samples where v is the replica test vessel number (N=3)
swithin,vwithin vessel Standard Deviation where v is the replica test vessel number (N=3)
CVwithin,vwithin vessel Coefficient of Variation where v is the replica test vessel number (N=3)
xavgaverage of 3 test vessels (3 samples per test vessel; blank corrected if the blank values are greater
than the reporting limit. Otherwise blank assumed as 0) (N=9)
sbetweenbetween vessel Standard Deviation (N=3)
CVbetweenbetween vessel Coefficient of Variation (N=3)
soverall Standard Deviation (N=9)
CVoverall Coefficient of Variation (N=9)
Table 2 24-hours Screening test at 100rpm ontest itemat a100mg/L loadingin a standard aqueous medium atpH 8. Data of measured dissolved vanadium concentrations, temperature, pH and dissolved oxygen concentration in test vessels.
(BLANK CORRECTED, if the blank value is higher than reporting limit, otherwise blank assumed as 0)
100 mg/L test item pH 8, 100 rpm |
µg/L V |
T (°C) |
pH |
DO (mg/L O2) |
|
Accredited reporting limit |
0.5 |
||||
Replica 1 |
Spl1 |
40.3 |
22.5 |
8.02 |
8.37 |
|
Spl2 |
40.9 |
|||
|
Spl3 |
41.2 |
|||
|
Xavg,1 |
40.8 |
|||
|
Swithin,1 |
0.4 |
|||
|
CVwithin,1(%) |
1 |
|||
Replica 2 |
Spl1 |
41.5 |
22.4 |
8.03 |
8.37 |
|
Spl2 |
42.2 |
|||
|
Spl3 |
41.7 |
|||
|
Xavg,2 |
41.8 |
|||
|
Swithin,2 |
0.4 |
|||
|
CVwithin,2(%) |
1 |
|||
Replica 3 |
Spl1 |
42.5 |
22.5 |
8.03 |
8.41 |
|
Spl2 |
41.7 |
|||
|
Spl3 |
41.7 |
|||
|
Xavg,3 |
41.9 |
|||
|
Swithin,3 |
0.5 |
|||
|
CVwithin,3(%) |
1 |
|||
Xavg |
41.5 |
|
|
|
|
Sbetween |
0.6 |
|
|
|
|
CVbetween(%) |
2 |
|
|
|
|
S |
0.7 |
|
|
|
|
CV |
2 |
|
|
|
xavg,vwithin vessel average of 3 samples where v is the replica test vessel number (N=3)
swithin,vwithin vessel Standard Deviation where v is the replica test vessel number (N=3)
CVwithin,vwithin vessel Coefficient of Variation where v is the replica test vessel number (N=3)
xavgaverage of 3 test vessels (3 samples per test vessel; blank corrected if the blank values are greater
than the reporting limit. Otherwise blank assumed as 0) (N=9)
sbetweenbetween vessel Standard Deviation (N=3)
CVbetweenbetween vessel Coefficient of Variation (N=3)
soverall Standard Deviation (N=9)
CVoverall Coefficient of Variation (N=9)
Description of key information
In a 24-hour screening study with a loading rate of 100 mg test item/L, an average vanadium concentration of 25.0 μg/L was measured at pH 6 and an average concentration of 41.5 μg/L was measured at pH 8. The screening study demonstrated that the highest release of vanadium from the test item occurs at pH 8. A 28-day transformation / dissolution study was therefore conducted at pH 8. At a loading rate of 1 mg/L, at pH 8, the average dissolved vanadium concentrations were 5.13 and 7.34 μg/L after 7 and 28 days, respectively.
Key value for chemical safety assessment
Additional information
The registered substance is not placed on the market as a discrete substance powder, but as a component in a mixture. Transformation / dissolution testing was therefore conducted with the product as placed on the market as the most realistic scenario.
Brouwers (2018a) is a GLP compliant study following OECD guideline 29 and is considered to be reliable without restrictions (Klimisch 1). A 24-hour screening study was conducted with a loading rate of 100 mg/L, at pH 6 and pH 8. Vanadium concentrations were analysed using ICP-MS.
For vanadium an average concentration of 25.0 μg/L was measured at pH 6. Based on the specific surface area of the test item, a release per surface of 0.0049 mg/m² V was calculated. Based on the vanadium content (1.61 % V) in the test item and the average dissolved vanadium concentrations in the test solutions, a vanadium release of 1.6 % was calculated as the 24 hours endpoint. For vanadium an average concentration of 41.5 μg/L was measured at pH 8. Based on the specific surface area of the test item, a release per surface of 0.0082 mg/m² V was calculated. Based on the vanadium content (1.61 % V) in the test item and the average dissolved vanadium concentrations in the test solutions, a vanadium release of 2.6 % was calculated at the 24 hours endpoint. In conclusion, the screening study demonstrated that the highest release of vanadium from the test item occurs at pH 8.
Based on the results from the screening study a 28 day transformation / dissolution study was conducted at pH 8. Brouwers (2018b) is a GLP compliant study following OECD guideline 29 and is considered to be reliable without restrictions (Klimisch 1). The test item was tested at a loading rate of 1 mg/L, for 28 days at pH 8. The average dissolved vanadium concentrations were 5.13 and 7.34 μg/L after 7 and 28 days, respectively. Based on the average vanadium content of the test item (1.61%), a vanadium release of 32% and 46% was calculated after 7 and 28 days, respectively. Based on the average exposed surface area of the test item (50.7 m2/g) a vanadium release per surface area of 0.10 mg/m² and 0.14 mg/m² was calculated at 7 and 28 days, respectively.
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