Vinylcyclohexane

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

The toxicology of vinylcyclohexane

Author:

Savchenkov M.F.

Year:

1965

Bibliographic source:

Gigiena i Sanitariya 30 Vol. 7, 32-37

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Vinylcyclohexane

EC Number:

211-779-3

EC Name:

Vinylcyclohexane

Cas Number:

695-12-5

Molecular formula:

C8H14

IUPAC Name:

ethenylcyclohexane

Test animals

Species:

mouse

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

The experiments were performed on white mice, some being healthy adult and young animals and some weakened by avitaminosis and insufficient feeding.

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: intact skin and tails
- % coverage: no data
- Type of wrap if used: no data

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure:no data

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): no data
- Constant volume or concentration used: no data

VEHICLE
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): no data
- Lot/batch no. (if required): no data
- Purity: no data

Duration of exposure:

Immersion of the tails: 2 hours

Doses:

no data

No. of animals per sex per dose:

no data

Control animals:

not specified

Details on study design:

- Application of Vinylcyclohexane on the intact skin
- Immersion of the tails of white mice into test tubes containing Vinylcyclohexane

Statistics:

no data

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

other: not specified

Remarks on result:

other: see Remarks

Remarks:

Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.

Gross pathology:

no data

Other findings:

no data

Any other information on results incl. tables

Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.

Executive summary:

Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.