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EC number: 945-713-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 December 2017 - 6 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Test method according to EEC method A.6. and OECD Guideline 105. GLP study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- < 0.23 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- ca. 5
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- (There was no chromatographic peak of any of the two components (viz. laevo alpha pinene and camphene) observed in shake flask analysis due to their negligible solubility in water. Thus, it is assumed a water solubility lower than LOD)
- Key result
- Water solubility:
- < 0.23 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- ca. 7
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- (There was no chromatographic peak of any of the two components (viz. laevo alpha pinene and camphene) observed in shake flask analysis due to their negligible solubility in water. Thus, it is assumed a water solubility lower than LOD)
- Key result
- Water solubility:
- < 0.23 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- ca. 9
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- (There was no chromatographic peak of any of the two components (viz. laevo alpha pinene and camphene) observed in shake flask analysis due to their negligible solubility in water. Thus, it is assumed a water solubility lower than LOD)
- Details on results:
- The solubility of reaction mass (fenchene, laevo alpha pinene, laevo camphene, dextro camphene) in all three buffers was
- Conclusions:
- The solubility of the test substance in three different buffers (pH=5, 7 and 9) is assumed to be below the detection limit of analytical method, i.e. 0.23 mg/L.
- Executive summary:
Determination of water solubility of the test substance was performed in accordance with EEC method A.6 and OECD 105. About five times higher quantity of test item determined in the preliminary test were weighed and transferred into three separate glass bottles of 125 mL capacity containing each 50 mL of buffer solution (pH=5). The same was repeated for buffer solution of pH=7 and pH=9. All the nine bottles were tightly stoppered and agitated at 30ºC using a thermostatically controlled orbital shaker. After 1 day, 2 days and 3 days, bottles were removed and kept for re-equilibration at 20ºC for 24 hours. The bottles were shaken occasionally during this period. Then the content of the bottles were separated using syringe having removable needle. The pH of solution was measured using a calibrated pH meter. The active ingredient concentration analysis was carried out using a validated analytical method. The solubility of the test substance in all three buffers was <LOD (0.23 mg/L). There was no chromatographic peak of any of the two components (viz. laevo alpha pinene and camphene) observed in shake flask analysis due to their negligible (very low) solubility in water. Thus, the solubility of the test substance in three different buffers (pH=5, 7 and 9) is assumed to be below the detection limit of analytical method, i.e. 0.23 mg/L.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Remarks:
- Data from a publication
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Data obtained from an acceptable standardized test method
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.037 other: mmol/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- Remarks on result:
- other: 95 % confidence limits: ± 0.004 mmol/L; Result 0.037± 0.004 mmol/L corresponds to 5.041± 0.5 mg/L
- Conclusions:
- The water solubility of L-alpha pinene at 25 °C is 0.037 ± 0.004 mmol/L, what corresponds to 5.04 ± 0.5 mg/L
- Executive summary:
A study on water solubility on several monoterpenes was conducted using a method similar to fllask method (OECD guideline 105). Under the test conditions, the water solubility of L-alpha pinene at 25 °C was determined to be 0.037 ± 0.004 mmol/L, what corresponds to 5.04 ± 0.5 mg/L.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Remarks:
- Data from a publication
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Documented study similar to an internationally accepted guideline.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.018 other: mmol/L
- Conc. based on:
- test mat.
- Temp.:
- 23.5 °C
- Remarks on result:
- other: CL: ± 0.0005 mmol/L; Result 0.0183± 0.0005 mmol/L which corresponds to 2.49± 0.07 mg/L
- Conclusions:
- The water solubility of D-alpha pinene at 23.5 °C is 0.0183 ± 0.0005 mmol/L, what corresponds to 2.49 ± 0.07 mg/L
- Executive summary:
A study on water solubility on several monoterpenes was conducted using a method similar to fllask method (OECD guideline 105). Under the test conditions, the water solubility of D-alpha pinene at 23.5 °C was determined to be 0.0183 ± 0.0005 mmol/L, what corresponds to 2.49 ± 0.07 mg/L.
- Endpoint:
- water solubility
- Type of information:
- other: Data from peer reviewed publication
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- No data on test method
- GLP compliance:
- not specified
- Type of method:
- other: Not specified
- Key result
- Water solubility:
- 4.6 mg/L
- Conc. based on:
- test mat.
- Remarks on result:
- other: No data on test conditions
- Conclusions:
- The water solubility of Camphene is 4.6 mg/L.
- Executive summary:
The water solubility of Camphene is 4.6 mg/L.
Referenceopen allclose all
Table 1. Results of the preliminary test
Solution |
Weight (g) of Test Item |
Volume (mL) of buffer added |
10 |
50 |
100 |
200 |
300 |
400 |
500 |
600 |
700 |
800 |
900 |
950 |
Approx. solubility (g/L) |
pH-5.0 |
0.02528 |
Solubility observed |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
Y |
0.0266 |
pH-7.0 |
0.02449 |
Solubility observed |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
Y |
0.0258 |
pH-9.0 |
0.02558 |
Solubility observed |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
Y |
0.0269 |
Key: N = No, Y = Yes
As the solubility of test item in the buffer waters was more than > 10-2 g/L, "Shake Flask Method" was adopted to determine its solubility in buffer waters.
Description of key information
Key study: Test item. Test method according to OECD 105 / EU Method A.6, GLP study. The solubility of the test substance in three different buffers (pH=5, 7 and 9) is assumed to be below the detection limit of analytical method, i.e. 0.23 mg/L.
Supporting study: Camphene. Data from peer review publication. The water solubility of Camphene is 4.6 mg/L.
Supporting study: L-alpha pinene. Data from publication. The water solubility of L-alpha pinene at 25 °C is 0.037 ± 0.004 mmol/L, what corresponds to 5.04 ± 0.5 mg/L.
Supporting study: D-alpha pinene. Data from publication. The water solubility of D-alpha pinene at 23.5 °C is 0.0183 ± 0.0005 mmol/L, what corresponds to 2.49 ± 0.07 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.23 mg/L
- at the temperature of:
- 20 °C
Additional information
Key study: Test item.Test method according to OECD 105 / EU Method A.6, GLP study. Determination of water solubility of the test substance was performed in accordance with EEC method A.6 and OECD 105. About five times higher quantity of test item determined in the preliminary test were weighed and transferred into three separate glass bottles of 125 mL capacity containing each 50 mL of buffer solution (pH=5). The same was repeated for buffer solution of pH=7 and pH=9. All the nine bottles were tightly stoppered and agitated at 30ºC using a thermostatically controlled orbital shaker. After 1 day, 2 days and 3 days, bottles were removed and kept for re-equilibration at 20ºC for 24 hours. The bottles were shaken occasionally during this period. Then the content of the bottles were separated using syringe having removable needle. The pH of solution was measured using a calibrated pH meter. The active ingredient concentration analysis was carried out using a validated analytical method. The solubility of the test substance in all three buffers was <LOD (0.23 mg/L). There was no chromatographic peak of any of the two components (viz. laevo alpha pinene and camphene) observed in shake flask analysis due to their negligible (very low) solubility in water. Thus, the solubility of the test substance in three different buffers (pH=5, 7 and 9) is assumed to be below the detection limit of analytical method, i.e. 0.23 mg/L.
Supporting study: Camphene. Data from peer review publication. The water solubility of Camphene is 4.6 mg/L.
Supporting study: L-alpha pinene. Data from publication. A study on water solubility on several monoterpenes was conducted using a method similar to fllask method (OECD guideline 105). Under the test conditions, the water solubility of L-alpha pinene at 25 °C was determined to be 0.037 ± 0.004 mmol/L, what corresponds to 5.04 ± 0.5 mg/L.
Supporting study: D-alpha pinene. Data from publication. A study on water solubility on several monoterpenes was conducted using a method similar to fllask method (OECD guideline 105). Under the test conditions, the water solubility of D-alpha pinene at 23.5 °C was determined to be 0.0183 ± 0.0005 mmol/L, what corresponds to 2.49 ± 0.07 mg/L.
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