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Diss Factsheets
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EC number: 292-146-9 | CAS number: 90552-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment of the toxicokinetics behaviour of the substance was performed using results from existing toxicological studies
- Objective of study:
- toxicokinetics
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment of the toxicokinetics behaviour of the substance was performed using results from existing toxicological studies
- GLP compliance:
- no
- Type:
- absorption
- Results:
- Adsorption via the oral is expected and was confirmed by experimental data. Dermal absorption is expected to be slow and limited but was not confirmed by experimental data.
- Type:
- distribution
- Results:
- The substance is expected to accumulate in adipose tissues.
- Details on absorption:
- Oral exposure: 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) is a highly hydrophobic and lipophilic substance (Log Kow > 6). These properties suggest that absorption of the substance would occur by micellar solubilisation following an exposure via the oral route. In addition the substance has a molecular weight below 500 Da which favours absorption in the gastrointestinal tract. Two animal studies were conducted via the oral route, one showing a dose-related, statistically significant increase in chloride level in male animals, suggesting that absorption occurred following an oral exposure
Inhalation exposure: 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) has a vapour pressure < 0.75 mmHg at 20°C therefore no exposure via inhalation to the substance as a vapour is expected. There is no data available on the effects of the substance following an inhalation exposure.
Dermal exposure: Since 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) has a molecular mass < 500 Da, it can theoretically be absorbed following a dermal exposure. 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) is poorly soluble in water (<< 1 mg/L) and has a high Log Kow (> 6). For a substance to partition from the stratum corneum into the epidermis, it must have a water solubility above 1 mg/L and a Log Kow < 4. Therefore considering the physicochemical properties of 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched), penetration across the skin is expected to be limited and very slow. 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) was not found to be irritant or corrosive to the skin, therefore it is not expected to damage the skin and thus enhance its dermal penetration. There is no data available on the systemic effects of the substance following a dermal exposure. - Details on distribution in tissues:
- 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) is a highly lipophilic substance. Following absorption it can therefore be expected to distribute into cells and to accumulate in adipose tissues. Two animal studies were performed 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched). Some general clinical signs were observed during them, however there were no specific signs of toxicity that would allow to comment on the distribution of the substance in a mammalian body.
- Details on excretion:
- There is no data available on the elimination of 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched).
- Metabolites identified:
- not measured
- Details on metabolites:
- There is no data available on the metabolisation of 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched).
- Conclusions:
- An assessment of the toxicokinetics behaviour of the substance was performed using results from existing toxicological studies.
- Executive summary:
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched).
However, it can be expected that the substance will be absorbed following an exposure via the oral route, which is supported by results of two animal studies performed on 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) using this route of exposure. No exposure to the substance via inhalation as a vapour is expected. In regards to the dermal route, absorption is expected to be negligible considering the properties of the substance.
Available data on 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) do not allow to assess the distribution, metabolisation and elimination of the substance.
Reference
Description of key information
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched).
It is expected that the substance will be absorbed following an exposure via the oral route, which is supported by results of two animal studies performed on 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) using this route of exposure. No exposure to the substance via inhalation as a vapour is expected. In regards to the dermal route, absorption is expected to be negligible considering the properties of the substance.
Available data on 2-Propenoic acid, 2-methyl-, tetracosyl ester(branched) do not allow to assess the distribution, metabolisation and elimination of the substance.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.