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Diss Factsheets
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EC number: 947-906-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- reconstituted water
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Healthy Daphnia magna (showing no signs of stress such as presence of males and ephippia, delay in the production of the first brood, discolouration, etc. and having normal behavior) less than 24 h old (first instar nymph) cultured and bred in the Laboratory of Ecotoxicology, Jai Research Foundation, were used for the study. The master culture of Daphnia magna was originally procured from the MicroBio Test Inc, Kleimoer 15, 9030 Mariakerke (Gent), Belgium. The test system was validated for its sensitivity by conducting a validation study (Kamle, M.K., 2017: JRF Study N° 502-3-07-17313) with potassium dichromate as a positive control.
Gravid females were acclimatised to the test conditions for a minimum period of 48 h. During this period, Daphnia were fed with live algal cells (Pseudokirchneriella subcapitata). Freshly hatched daphnids belonging to the same stock (less than 24 h-old) were collected with the help of a micropipette and was used for the study. Feed was not provided during the exposure period. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 184.8 mg/L as CaCO3
- Test temperature:
- 19.9 °C - 20.1 °C
- pH:
- 7.44 - 7.70
- Dissolved oxygen:
- 8.30 - 8.71 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate as a positive control
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: LD50 (48 h) > 100 mg/L
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: LD 50 (24 h) > 100 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 (24 and 48 h), NOEC and LOEC: Greater than the test concentration of 100.0 mg test item/L.
EC50 (24 and 48 h), NOEC and LOEC: > 100.0 mg/L. (Dissolved fraction of Test substance) - Executive summary:
This study was performed to assess the toxic effects of the test substance on Daphnia magna under static conditions.
Based on the results of the preliminary range finding study, the main study was restricted to limit study and it was performed at the nominal test concentration of 100.0 mg/L. In the main study, a 48 h static toxicity test procedure was followed, comprising three groups. Each group consisted of four replicates with 5 daphnids per replicate.
As the study was conducted as a limit test of 100.0 mg test item/L and no immobility observed up to 48 h,
24 and 48 h, EC50 considered to be greater than test concentration of 100.0 mg test item/L as the test was performed for dissoved fraction of 100 mg test substance/ L.
Reference
Description of key information
This study was performed to assess the toxic effects of the test substance on Daphnia magna under static conditions.
Based on the results of the preliminary range finding study, the main study was restricted to limit study and it was performed at the nominal test concentration of 100.0 mg/L. In the main study, a 48 h static toxicity test procedure was followed, comprising three groups. Each group consisted of four replicates with 5 daphnids per replicate.
As the study was conducted as a limit test of 100.0 mg test item/L and no immobility observed up to 48 h,
24 and 48 h, EC50 considered to be greater than test concentration of 100.0 mg test item/L as the test was performed for dissoved fraction of 100 mg test substance/ L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
As the study was conducted as a limit test of 100.0 mg test item/L and no immobility observed up to 48 h,
24 and 48 h, EC50 considered to be greater than test concentration of 100.0 mg test item/L as the test was performed for dissoved fraction of 100 mg test substance/ L.
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