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Diss Factsheets
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EC number: 701-357-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 05, 2018 to December 06, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181
- Version / remarks:
- CIPAC MT 181: “Solubility in organic solvents”, CIPAC Handbook H, 1998
- Deviations:
- no
- Principles of method if other than guideline:
- The study was performed in order to determine the miscibility of test substance with solvent n-octanol according to CIPAC MT 181. The test substance was mixed with different amounts of n-octanol. From the total volume, which was required for complete dissolution of a certain mass of the test substance, examined visually after at least 30 minutes, the solubility in n-octanol was determined.
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 33 - ca. 40 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: equivalent to 13-16 g a.i./L
- Test substance stable:
- not determined
- Conclusions:
- Under the study conditions, the n-octanol solubility of the test substance was determined to be 33 -40 g/L of solution at 20.0 ± 0.5°C (equivalent to 13 -16 g a.i./L).
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, C12 -14 HEDMAC ( 39.6% active) using a measuring test tube method according to CIPAC MT 181, in compliance with GLP. Under the study conditions, the n-octanol solubility of the test substance was determined to be 33 -40 g/L of solution at 20.0 ± 0.5°C (equivalent to 13-16 g a.i./L) (Brinkmann, 2019).
Reference
Results
Pre-Test n-octanol
Weight test substance [g] |
0.999 |
|||
Added Volume [mL] |
0.5 |
1.0 |
2.0 |
3.0 |
Approx.Solubility[g/L] |
> 200 |
100-200 |
50-100 |
33-50 |
Dissolution |
no |
no |
nearly |
Yes* |
*No Tyndall effect was visible with the Laser pointer.
In n-octanol dissolution of 33 – 50 g/L of the test substance was observed.
Main-Test
Determination |
1 |
2 |
||||
Weight test substance [g] |
0.1007 |
0.1012 |
||||
Added Volume[mL] |
2.0 |
2.5 |
3.0 |
2.0 |
2.5 |
3.0 |
Approx. Solubility [g/L] |
> 50 |
40-50 |
33-40 |
> 50 |
40-50 |
33-40 |
Dissolution |
no |
no |
yes* |
no |
no |
yes* |
*No Tyndall effect was visible with the Laser pointer.
Discussion
The results of the pre-test (33 – 50 g/L) were confirmed in the main test (33 -40 g/L). The main test showed good repeatability. Solubility in n-octanol is 33 – 40 g/L. Solubility in n- octanol, calculated based on active matter content (content of UVCB component Quaternary ammonium compounds, C12-14alkyl(hydroxyethyl)dimethyl, chlorides in the test substance: 39.6%) is 13 – 16 g/L. No doubts have arisen concerning the accuracy of the results and the validity of the study.
Description of key information
The solubility in organic solvents of the test substance (39.6% active) was determined using the flask method, according to CIPAC MT 181 (Brinkmann, 2012).
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 16 g/L
Additional information
(n-octanol solubility: 13 -16 g a.i./L)
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