Registration Dossier
Registration Dossier
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EC number: 290-505-4 | CAS number: 90170-70-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
- Bacterial Reverse Mutation Test (B.13/14, GLP), with and without metabolic activation, S.typhimurium TA98, TA100, TA 1535 and TA1537, E.coli WP2 uvrA:
-Mutagenic for tester strains S. typhimurium TA 98 with and without metabolic activation and equivocal results for TA1537 with metabolic activation,
-Non-mutagenic for: TA 100, TA 1535 and E.Coli, with and without metabolic activation, and TA 1537 without metabolic activation
Chromosome aberration test to CHL/IU cells in vitro: Negative
Read Across to Analogue Substance (Solvent Blue 98):
In-vitro chromosomal abberation test (OECD 473): Negative: Not genotoxic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
Read Across to Analogue Substance (Solvent Blue 98):
In vivo mutagenicity assay (Pig A) integrated into the OECD 422 assay.
Negative: Not genotoxic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Although a positive baceterial mutagenicity assay indicated a potential for mutagenicity in vitro, a Chromosome aberration test to CHL/IU cells in vitrogave a negative result. In addition
read ascross to an Analogue substance in vivo mutagenicity assay (pig A) was negative and a chromosomal abberation test (OECD 473) for the analogue substance was also negative (despite also giving a positive result in an Ames study). Consequently it is concluded that at this time, the substance does not meet the criteria for classification for mutagenicity.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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