Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 908-700-6 | CAS number: 64519-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Feb - 27 Feb 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- effusion method: Knudsen cell
- Remarks:
- vapour pressure calculated by extrapolation of measured values
- Specific details on test material used for the study:
- Store at ambient temperature, dry
- Temp.:
- 20 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 50 °C
- Vapour pressure:
- 0 hPa
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Feb - 08 Mar 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- effusion method: Knudsen cell
- Remarks:
- vapour pressure calculated by extrapolation of measured values
- Specific details on test material used for the study:
- Store at ambient temperature, dry
- Temp.:
- 20 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 50 °C
- Vapour pressure:
- 0 hPa
Referenceopen allclose all
Thermal Stability
The DSC showed that in the temperature ranges of 70 °C – 110 °C and 110
°C – 150 °C the test item showed two endothermic effects, which can be
assigned to a separation of crystallisation water and the melting of the
test item (see study reference ‘4.12 Auto-flammability and 4.13
Flammability_Self-heating properties of substances and mixtures’).
Starting at a temperature of 240 °C, an exothermic effect was observed,
which was not finished up to the maximum test temperature of 300 °C. Due
to this, this exothermic effect has decomposition energy of greater than
-250 J/g.
Table 1 – DSC measurement results
Sample weight [mg] |
Start [°C] |
Energy [J/g] |
9.48 |
70 (endothermic) |
20 |
Effusion Method: Knudsen cell
The vapour pressure was measured in the temperature range of
120.9 °C to 140.8 °C. The measured vapour pressure values together with
the measured temperatures are listed in Table 2.
Table 2 – Effusion method results
No. |
Temperature [°C] |
Vapour pressure [Pa] |
1 |
120.9 |
4.0 × 10-3 |
2 |
125.9 |
5.0 × 10-3 |
3 |
130.9 |
6.2 × 10-3 |
4 |
135.8 |
7.4 × 10-3 |
5 |
140.8 |
8.7 × 10-3 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine Equation
Log p = A + B/T = A + B/(C+ϑ)
were derived by regression of the data points to
A = 4.5847
B = -2748.06
C = 273.15.
The vapour pressure of the test item Isomalt-ST Typ PF
calculated by extrapolation of the measured vapour pressure curve for
the temperatures 20 °C, 25 °C and 50 °C, according to Regulation EC
No. 440/2008 Method A.4.Vapour Pressure and OECD Test Guideline 104
(2006) is shown in table 3.
Table 3 - Calculated vapour pressure values for 20 °C, 25 °C
and 50 °C
Temperature [°C] |
Vapour pressure [Pa] |
20 |
1.6 × 10 -5 |
25 |
2.3 × 10 -5 |
50 |
1.2 × 10 -4 |
Thermal Stability
The DSC showed that in the temperature ranges of 80 °C – 110 °C and 110
°C – 160 °C the test item showed two endothermic effects, which can be
assigned to a separation of crystallisation water and the melting of the
test item (see study reference ‘4.12 Auto-flammability and 4.13
Flammability_Self-heating properties of substances and mixtures’).
Starting at a temperature of 240 °C, an exothermic effect was observed,
which was not finished up to the maximum test temperature of 300 °C. Due
to this, this exothermic effect has decomposition energy of greater than
-250 J/g.
Table 1 – DSC measurement results
Sample weight [mg] |
Start [°C] |
Energy [J/g] |
9.02 |
80 (endothermic) |
30 |
Effusion Method: Knudsen cell
The vapour pressure was measured in the temperature range of
110.9 °C to 130.8 °C. The measured vapour pressure values together with
the measured temperatures are listed in Table 2.
Table 2 – Effusion method results
No. |
Temperature [°C] |
Vapour pressure [Pa] |
1 |
110.9 |
1.0 × 10-3 |
2 |
115.9 |
1.9 × 10-3 |
3 |
120.9 |
3.3 × 10-3 |
4 |
125.9 |
5.6 × 10-3 |
5 |
130.9 |
7.7 × 10-3 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine Equation
Log p = A + B/T = A + B/(C+ϑ)
were derived by regression of the data points to
A = 14.9635
B = -6882.85
C = 273.15
The vapour pressure of the test itemIsomalt-GS Typ PF
calculated by extrapolation of the measured vapour pressure curve for
the temperatures 20 °C, 25 °C and 50 °C, according to Regulation EC
No. 440/2008 Method A.4.Vapour Pressure and OECD Test Guideline 104
(2006) is shown in table 3.
Table 3 - Calculated vapour pressure values for 20 °C, 25 °C
and 50 °C
Temperature [°C] |
Vapour pressure [Pa] |
20 |
3.1 × 10-9 |
25 |
7.6 × 10-9 |
50 |
4.6 × 10-7 |
Description of key information
3.1E-11 hPa to 1.6E-07 hPa at 20 °C (Extrapolation of measured vapour pressure using Effusion method, OECD 104)
The result is given as a range based on the results obtained from two types of Isomalt (ST and GS).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.