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Diss Factsheets
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EC number: 209-665-3 | CAS number: 589-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1943
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Lack of substance identity information with respect to isomers. Non-standard repeated dosing. Inadequate follow up period.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 943
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- no guideline followed
- Principles of method if other than guideline:
- The study reported toxicity following dermal exposure to meta and para-methylcyclohexanone isomers. For the dermal toxicity investigations, the liquid was administered by dropping a measured amount of the substance on the clipped skin area of a rabbit in multiple separate applications, until the desired dose was achieved over a period of hours. The skin was then washed.
- GLP compliance:
- no
- Test type:
- other: non-standard
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylcyclohexanone
- EC Number:
- 209-665-3
- EC Name:
- 4-methylcyclohexanone
- Cas Number:
- 589-92-4
- Molecular formula:
- C7H12O
- IUPAC Name:
- 4-methylcyclohexan-1-one
- Reference substance name:
- 3-methylcyclohexanone
- EC Number:
- 209-710-7
- EC Name:
- 3-methylcyclohexanone
- Cas Number:
- 591-24-2
- Molecular formula:
- C7H12O
- Test material form:
- liquid
- Details on test material:
- - Density: 0.914
- Boiling point: 169-170.5°C
- Refractive index: 1.4458
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL:
Barrett Division of Allied Chemical and Dye Corporation.
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
Not reported.
Test animals
- Species:
- rabbit
- Strain:
- other: White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: local breeders
- Age at study initiation: young
- Weight at study initiation: not reported
- Fasting period before study: not reported
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: until observed to be healthy.
ENVIRONMENTAL CONDITIONS: Not reported.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 24 square inches
- Type of wrap if used: none
REMOVAL OF TEST SUBSTANCE
- Washing (if done): soap and water
- Time after start of exposure: 20min after last application
TEST MATERIAL
- Amount(s) applied: 5mL every 20min until the desired dose was achieved - Duration of exposure:
- several hours
- Doses:
- 15mL (4900mg/kg bw), 20mL (7200mg/kg bw), 35mL (13400mg/kg bw)
- No. of animals per sex per dose:
- one animal per dose (total of three)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: approximately four hours for the single surviving animal
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Remarks:
- lowest dose with mortality
- Effect level:
- 7 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality was observed 2h 10min after dosing for both animals with 7200 and 13400 mg/kg bw dose levels.
- Clinical signs:
- other: After dermal application narcosis was induced with tremors and convulsive movements. Narcosis lasted for 2h for the one surviving animal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The lowest reported lethal dose was 7.2 grams/kg. An LD50 was not reported. The substance when dermally applied, produced hypothermia, narcosis and convulsive movements.
- Executive summary:
Methylcyclohexanone was applied in 5 ml portions to the skin of 3 rabbits in 20 minutes intervals. The skin was washed 20 minutes after the last application. Doses of 4.9g/kg bw, 7.2g/kg bw and 13.4g/kg were applied. The substance produced hypothermia, narcosis and convulsive movements. Mortality was observed in the two highest doses, while the lowest dose animal recovered.
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