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Diss Factsheets
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EC number: 283-563-7 | CAS number: 84682-03-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- The Effects of Zinc Supplements on Lipoproteins and Copper Status
- Author:
- Samman S & Roberts DCK
- Year:
- 1 988
- Bibliographic source:
- Atheroscl. 70:247-252
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- repeated dose toxicity: oral
- Principles of method if other than guideline:
- A double-blind cross-over trial was conducted on healthy human volunteers for 12 wks to evaluate the effect of the test material on plasma lipoproteins.
- GLP compliance:
- no
Test material
- Reference substance name:
- Zinc sulphate
- EC Number:
- 231-793-3
- EC Name:
- Zinc sulphate
- Cas Number:
- 7733-02-0
- Molecular formula:
- H2O4S.Zn
- IUPAC Name:
- zinc sulfate
- Details on test material:
- - Name of test material (as cited in study report): Zinc sulfate
- Other: Obtained from Zincaps, Protea Pharmaceuticals
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 47
- Sex: 26 female and 21 male
- Age: 27 yr (female) and 28 yr (male)
- Demographic information: Females weighing less than males
- Other: Subjects were asked not to change their lifestyle pattern and particularly habits known to alter lipid metabolism (ingestion of alcohol, diet, exercise and smoking) - Ethical approval:
- confirmed and informed consent free of coercion received
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- Double-blind cross-over trial, 50 mg Zn (as ZnSO4) or placebo (lactose) was administered to healthy volunteers three times a day for six weeks. Volunteers were allocated randomly to Zn treatment for six weeks followed by placebo regimen for six weeks, or vice versa.
- Examinations:
- - Estimation of plasma lipoproteins: Total cholesterol, HDL & LDL-cholesterol
- Estimation of plasma Zn levels
- Estimation of Cu status by haematocrit measurements and estimation of ferroxidase activity of serum caeruloplasmin and antioxidant activity of Erythrocyte superoxide dismutase (E-SOD) & CuZn E-SOD - Medical treatment:
- No
Results and discussion
- Clinical signs:
- Gastrointestinal symptoms
- Results of examinations:
- Plasma lipoproteins:
- Total cholesterol: Remains unchanged in male/female
- LDL-cholesterol: In females, decreased from 2.38 to 2.17 mmol/L; no effect in males
- Ferroxidase activity of serum caeruloplasmin: In females, reduced from 13.0 to 11.3 U/mL; no effect in males
- Antioxidant activity of E-SOD: In females, reduced from 4,557 to 3,638 U/g Hb; no effect in males
- Antioxidant activity of E-SOD: In females, reduced from 2,184 to 1,672 U/g Hb; no effect in males
- Plasma Cu and haematocrit: Remains unchanged in male/female - Effectivity of medical treatment:
- Not applicable
- Outcome of incidence:
- Not applicable
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, the test material reduced LDL-cholesterol, ferroxidase activity of serum caeruloplasmin and antioxidant activity of E-SOD & CuZn E-SOD in females whereas no effect observed in males.
- Executive summary:
A double-blind cross-over trial was conducted on 47 (26 female & 21 male) healthy human volunteers for 12 wks to evaluate the effect of the test material (50 mg Zn as ZnSO4 or placebo, three times a day, for six weeks) on plasma lipoproteins.
Under the test conditions, the test material reduced mean LDL-cholesterol level, ferroxidase activity of serum caeruloplasmin and antioxidant activity of E-SOD & CuZn E-SOD in females whereas no effect observed in males.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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