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Diss Factsheets
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EC number: 916-807-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of 1,2,3,4,5,6,7,8-octahydro-5,5-dimethylnaphthalene-2-carbaldehyde and 1,2,3,4,5,6,7,8-octahydro-8,8-dimethyl-2-naphthaldehyde
- EC Number:
- 916-807-4
- Molecular formula:
- C13H20O
- IUPAC Name:
- Reaction mass of 1,2,3,4,5,6,7,8-octahydro-5,5-dimethylnaphthalene-2-carbaldehyde and 1,2,3,4,5,6,7,8-octahydro-8,8-dimethyl-2-naphthaldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Description: Clear liquid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300g
- Fasting period before study: 18 hours
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 1220, 2470, 5000, 10140 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: mortality, toxicity, pharmacological effects, gross pathology
- Frequency of observations: daily - Statistics:
- LD50 and 95% Confidence Limits were calculated by the method of Litchfield and Wilcoxon (J. Phar. & Exp. Therap. 96:99, 1949)
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 800 - <= 5 900
- Mortality:
- 1220 mg/kg bw: No mortality
2470 mg/kg bw: 1/10 (One animal died on day 1)
5000 mg/kg bw: 7/10 (Four animals died on day 1; two animals died on day 2, and one animal died on day 7)
10140 mg/kg bw: 10/10 (Six animals died on day 1; three animals died on day 2, and one animal died on day 7) - Clinical signs:
- other: 1220 mg/kg bw: diarrhea, lethargy, ptosis 2470 mg/kg bw: lethargy, diarrhea, flaccid tone 5000 mg/kg bw: diarrhea, lethargy, flaccid tone, ataxia, ptosis, piloerection, coma. 1/4 survivors on day 4 had hair loss on head and neck 10140 mg/kg bw: diarrhea,
- Gross pathology:
- 1220 mg/kg bw: No abnormalities observed
2470 mg/kg bw: The animal who died had red exudate of the nose/mouth region, yellow exudate of the anogenital region, red areas in the intestines, dark liver, dark lungs, and dark kidney. Of the nine animals who were sacrificed after 14 days, in 6 animals, no abnormalities were observed and in 3 animals dark areas in the lung were observed.
5000 mg/kg bw: In the seven animals who died the following observations were made: Red exudate of the nose/mouth region (2/7), Red exudate of the nose/mouth region (4/7), Brown exudate of the anogenital region (7/7), Red areas in the intestines (6/7), Bloated intestines (5/7), Stomach, liver and intestines covered by white opaque substance (1/7), Mottled liver (2/7), Dark lungs (3/7), Dark areas in the lung (4/7), Dark kidney (3/7), and Mottled spleen (1/7). In the animals who were sacrificed after 14 days no abnormalities were observed.
10140 mg/kg bw: The following observation were made: Red exudate of the nose/mouth region (10/10), Yellow exudate of the anogenital region (10/10), Red areas in the intestines (2/10), Bloated intestines (1/10), Bloated stomach (1/10), Dark liver (4/10), Mottled liver (6/10), Dark areas in the lung (10/10), Dark kidney (10/10), Dark spleen (3/10), Small spleen (1/10)
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
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