Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative Effects of Ethanol , n-Propanol add Isopropanol on Lipid Disposal by Rat Liver
- Author:
- Beaugé F., Clement M., Nordmann J., Nordmann r
- Year:
- 1 979
- Bibliographic source:
- Chem.-Biol. Interactions, 26, 155-166
Materials and methods
- Objective of study:
- absorption
- metabolism
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- Propan-1-ol
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
Doses / concentrations
- Dose / conc.:
- 3 005 mg/kg bw/day (nominal)
- No. of animals per sex per dose / concentration:
- 3
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The propan-1-ol concentration in blood serum peaked one hour after administration. a peak blood level of approximately 1800 mg/l after about 1.5 hours could be derived. Thereafter blood levels decreased rapidly to below detection limits (5 h after dosing)
The rate of metabolism of n-propanol was 510 mg (8.5 mmol)/kg/h.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
