Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-700-3 | CAS number: 98-79-3
Endpoint summary
Administrative data
Description of key information
After 96 hours exposure to 4.27, 9.39, 20.7, 45.5 and 100 mg (2S)-5-oxopyrrolidine-2-carboxylic acid/L treatment rates, observed mortality was 0% in all test concentrations.Therefore, the 96-hour LC50 is >100 mg (2S)-5-oxopyrrolidine-2-carboxylic acid/L. Sublethal effects were observed in the 45.5 and 100 mg (2S)-5-oxopyrrolidine-2-carboxylic acid/L treatment rates. The NOEC was 100 mg (2S)-5-oxopyrrolidine-2-carboxylic acid/L and LOEC was >100 mg (2S)-5-oxopyrrolidine-2-carboxylic acid/L.
In a 48-hour study the acute toxicity of the aquatic invertebrateDaphnia magnawas studied. The 48-hour EC50 (immobility) was determined to be >94.1 mg/L under the conditions of the test.
In a 72 -hour toxicity study the green alga, Pseudokirchenriella subcapitata, was exposed to a range of test concentrations under static conditions in accordance with the OECD test guideline 201 and in compliance with GLP. The 72 hour ErC50 (growth rate) was determined as >4.41 mg/L and the EyC50 (biomass) was determined to be 2.81 mg/L based on geometric mean measured test concentrations
According to the Column 2 of the Annex VIII of the Regulation (EC) No 1907/2006, toxicity to micro-organisms in activated sludge does not need to be conducted if the substance is readily biodegradable and the applied test concentrations are in the range of concentration that can be expected in the influent of a STP. The readily biodegradability test has been conducted with concentrations of 100 mg/L showing readily biodegradability behaviour (OECD 301 Ready Biodegradability; Laboratoire deChimie-Ecotoxicologie 402/16/1215F/a-e; Jequel, M; 2017). Therefore toxicity to micro-organisms in activated sludge test is not required.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
