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EC number: 216-835-0 | CAS number: 1678-91-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-01-20 - 1992-04-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ethylcyclohexane
- EC Number:
- 216-835-0
- EC Name:
- Ethylcyclohexane
- Cas Number:
- 1678-91-7
- Molecular formula:
- C8H16
- IUPAC Name:
- ethylcyclohexane
- Test material form:
- liquid: volatile
Constituent 1
- Specific details on test material used for the study:
- SRI1D or Lot I.D. Number: 7482-9A
Physical State and Appearance: Colorless liquid
Test animals
- Species:
- rat
- Strain:
- other: CD(SD)BR VAF/Plus
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Housing:
All animals were individually housed in suspended, stainless-steel, mesh cages.
Environmental Conditions:
A photoperiod of 12 hours light from 6 a.m. to 6 p.m. Room temperature was maintained at
74-75*F. Relative humidity was maintained-at 45-47%.
Diet and Water:
ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- A single dose of the test material was administered by gavage to animals that had been fasted
overnight. - Doses:
- 2000 mg compound/kg body weight
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- Clinical Observations:
Animals were observed at least three times on the day of dosing (Day 0), and once each workday thereafter for the duration of the experiment (a total of 14 calendar days). Observation included, but was not limited to: examination of the hair, skin, eyes, motor activity, feces, and urine. Animals were checked for mortality on weekend days.
Body Weight Determinations:
Body weights were collected on the day of dosing (Day 0), Day 7, and Day 14 of the study.
Necrosy:
All animals were necropsied at the completion of the 14-day observation period.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Discolored (light-brown) feces were noted from all animals on the day following dosing.
- Gross pathology:
- Minimal hyperkeratosis of the non-glandular gastric mucosa. for all males and three of five females.
Any other information on results incl. tables
Summary Table
DOSE (mg/kg) |
NUMBER OF RATS DOSED (M,F) |
NUMBER OF DEATHS <M,F) |
TIME OF DEATH |
WEIGHT GAIN* (M,F) |
|
I WEEK |
2WEEKS |
||||
2000 |
5,5 |
0,0 |
— |
5 +,5 + |
5 +,5 + |
*+ =Number of animals gaining weight -=Number of animals losing weight
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was a gastric irritant as evidenced by hyperkeratosis of the non-glandular gastric mucosa. The acute oral LD50 for this test material was greater than 2000 mg/kg for male and female rats.
- Executive summary:
An acute oral toxicity study was conducted in male and female rats administered a single limit dose of 2000 mg/kg of the test material by gavage. Discolored (light-brown) feces were noted from all animals on the day following dosing. No other abnormal clinical signs were observed during the 14-day observation period. No mortality was observed, and all animals
gained weight normally. Treatment-related changes observed at necropsy were limited to minimal hyperkeratosis of the non-glandular gastric mucosa for all males and three of five females. No other treatment-related changes or signs of organ toxicity were noted at necropsy. In the absence of significant gross organ lesions, other than the obvious signs of
gastric irritation, no tissue was collected for histological examination.
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