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EC number: 605-708-9 | CAS number: 174125-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-11-02 - 1995-11-16 (Experimental phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- OECD Guideline for Testing of Chemicals No. 401 "Acute Oral Toxicity". Adopted: 24 February 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- bis(O,O-2-ethylhexyl-thiophosphoryl)polysulfide
- EC Number:
- 605-708-9
- Cas Number:
- 174125-93-0
- Molecular formula:
- n.a.
- IUPAC Name:
- bis(O,O-2-ethylhexyl-thiophosphoryl)polysulfide
- Test material form:
- liquid
- Remarks:
- Orange/brown
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Hsd/Ola:Sprague-Dawley(CD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Ltd., Bicester, Oxon, England
- Age at study initiation: approximately four to seven weeks
- Weight at study initiation: 100 to 118 g
- Fasting period before study: Access to food only was prevented overnight prior to and approximately 2 hours after dosing.
- Housing: The rats were allocated without conscious bias to cages within the treatment groups. They were housed in groups of up to five rats of the same sex in metal cages with wire mesh floors.
- Diet (e.g. ad libitum): A standard laboratory rodent diet (SDS LAD 1) was provided ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: All the rats were acclimatised to the experimental environment for a period of seven days prior to the start of the study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Animal room temperature was set to achieve a temperature of 22 + 3°C.
- Humidity (%): Relative humidity was not controlled but was anticipated to be in the range 30 - 70% RH.
Permanent daily recordings of these parameters were made and these are archived with other Department raw data. Any slight deviation in temperature and humidity that may have occurred was not considered to have affected the integrity or validity of the study
- Air changes (per hr): Air exchange was maintained at 10 to 15 air changes per hour.
- Photoperiod (hrs dark / hrs light): Lighting was controlled by means of a lime switch to provide 12 hours of artificial light (0700 ― 1900 hours) in each 24-hour period.
The rat was chosen as it has been shown to be a suitable model for this type of study and is the animal recommended in the test guideline.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
none used
MAXIMUM DOSE VOLUME APPLIED: 1.9 ml
DOSAGE PREPARATION (if unusual): The test item was administered, as supplied, at a volume of 1.9 ml/kg bodyweight (specific gravity 1.0484). - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 / sex / dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Mortality: Cages of rats were checked at least twice daily for any mortalities.
Clinical signs: Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1 (a period of approximately three hours). On subsequent days animals were observed once in the morning and again at the end of the experimental day (with the exception of Day 15 - morning only). This latter observation was at approximately 16.30 hours on week days or 11.30 hours on Saturdays and Sundays. The nature and severity of the clinical signs and time were recorded at each observation.
Bodyweight: The bodyweight of each rat was recorded on Days 1 (prior to dosing), 8 and 15. Individual weekly bodyweight changes and group mean bodyweights were calculated.
- Necropsy of survivors performed: yes
Macroscopic pathology: All animals were subjected to a macroscopic examination which consisted of opening the abdominal and thoracic cavities. The macroscopic appearance of all tissues was recorded.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths following a single oral dose of the test item to a group of ten rats (five males and five females) at a dosage of 2.0 g/kg bodyweight.
- Clinical signs:
- other: Piloerection was observed in all rats within ten minutes of dosing. This sign persisted and was accompanied in all animals on Day 2 only by soft to liquid faeces. There were no other clinical signs and recovery, as judged by external appearance and behavi
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- EU implementation
- Conclusions:
- The study was conducted under GLP according to OECD TG 401 on the registered substance itself. The method is to be considered scientifically reasonable with no deficiencies. Hence, the results can be considered as sufficiently reliable to assess the acute oral toxicity in rats. The determined LD50 value is >2000 mg/kg bw, the LD0 ≥ 2000 mg/kg, as none of the animals died after gavage of 2000 mg/kg bw. The result is suitable to determine the classification of the test item. According to Regulation (EC) No. 1272/2008, the substance does not need to be classified as acute toxic cat. IV or higher.
- Executive summary:
A study was performed to assess the acute oral toxicity of the test item to rats. The method followed was that described in OECD Guideline for Testing of Chemicals No. 401 "Acute Oral Toxicity", Adopted: 24 February 1987.
A group of ten fasted rats (five males and five females) was given a single dose by oral gavage of the test substance, as supplied, at a dose level of 2.0 g/kg bodyweight. All animals were killed and examined macroscopically on Day 15, the end of the observation period.
There were no deaths. Clinical signs of reaction to treatment were confined to piloerection and soft to liquid faeces, seen in ail rats. Recovery was complete in all instances by Day 3.
All rats achieved satisfactory bodyweight gains throughout the study.
No abnormalities were recorded at the macroscopic examination on Day 15.
The acute lethal oral dose to rats of Bis(O,O-2-ethylhexyl-thiophosphoryl)polysulfide was found to be greater than 2.0 g/kg bodyweight, the substance does not need to be classified as acute toxic cat. IV or higher according to Regulation (EC) No. 1272/2008.
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