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EC number: 812-962-6 | CAS number: 34354-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-04-21 to 2017-10-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- adopted on 27 July 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- Council Regulation (EC) No 440/2008; May 30th 2008
- GLP compliance:
- no
- Type of method:
- other: thermogravimetry and differential scanning calorimetry
Test material
- Reference substance name:
- Ceramide III
- IUPAC Name:
- Ceramide III
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- The physical state of the test item at 20 °C and 101.3 kPa is a white, crystalline solid. All analyses included in this report have been performed with a batch, which passed the quality control measurements without any irregularity previously. All specifications were met.
Results and discussion
Boiling point
- Key result
- Decomposition:
- yes
- Decomp. temp.:
- > 240 °C
- Remarks on result:
- other: The recorded weight loss above 340.6 °C may indicate a beginning evaporation (boiling). Based on visual inspection and the DSC test, where the test item showed a significant change of the melting behaviour, a product decomposition is more likely.
Any other information on results incl. tables
Results
Capillary method
The thermic behaviour of Ceramide III was tested with a boiling point capillary from room temperature up to 300 °C with a heating rate of 10 °C/min. Arising bubbles were observed from approx. 190 °C. Finally, after cooling, the content of the tube appeared coloured and brownish.
DSC / TGA
As preliminary tests first TGA and DSC runs were performed. As the substance was obviously modified within the first heating period to 250 °C, the DSC main test was focussed on the melting behaviour.
Evaluation
In the TGA test, a sample of the test item was heated from 30 °C to 675 °C in an inert gas atmosphere (nitrogen). The main drop was detected beginning at 340.6 °C (onset). Up to 460 °C a total weight loss of 99.9 % was recorded.
The recorded main weight loss above 340.6 °C (estimated onset on TGA) may indicate a beginning evaporation (boiling). However, based on the visual inspection and the results of the DSC preliminary test (up to 250 °C) where the test item showed a significant change of the melting behaviour (change of the melting point from 126.2 °C to < 80 °C (peak top)) a product decomposition is more likely.
In order to provide evidence for this assumption, a degradation test was performed during which an aliquot of the sample was heated to 240 °C for 15 minutes. The remaining residue (98.1 % of the original material) was characterised by NMR spectroscopy. The NMR analysis confirms the decomposition of the product. Less than 50 % of the original material were detected after heating. Consequently, the test item does not provide a boiling point until disintegration at about 240 °C.
Applicant's summary and conclusion
- Conclusions:
- The test item does not provide a boiling point until disintegration at about 240 °C.
- Executive summary:
The boiling point of Ceramide III was determined according to OECD Guideline 103 (27 July 1995) and EU Method A.2 (30 May 2008) using differential scanning calorimetry, thermogravimetry, NMR analysis and visual inspection.
In the TGA test, a sample of the test item was heated from 30 °C to 675 °C. The main drop was detected beginning at 340.6 °C (onset). Up to 460 °C a total weight loss of 99.9 % was recorded.
The recorded main weight loss above 340.6 °C (estimated onset on TGA) may indicate a beginning evaporation (boiling). However, based on the visual inspection and the results of the DSC preliminary test (up to 250 °C) where the test item showed a significant change of the melting behaviour (change of the melting point from 126.2 °C to < 80 °C (peak top)) a product decomposition is more likely.
In order to provide evidence for this assumption, a degradation test was performed during which an aliquot of the sample was heated to 240 °C for 15 minutes. The remaining residue (98.1 % of the original material) war characterised by NMR spectroscopy. The NMR analysis confirmed the decomposition of the product. Less than 50 % of the original Ceramide III material were detected after heating. Consequently, Ceramide III does not provide a boiling point until disintegration at about 240 °C.
Boiling point of Ceramide III: no boiling point, but decomposition > 240 °C.
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