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Diss Factsheets
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EC number: 947-646-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed by a GLP accredited laboratory although this study was not performed to GLP. The procedures used in the study were based on EEC methodology and are sufficient to conclude on the classification and labeling of the substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of mixed xylenes and sulphur monochloride
- IUPAC Name:
- Reaction mass of mixed xylenes and sulphur monochloride
- Reference substance name:
- DXDS
- IUPAC Name:
- DXDS
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): DXDS (Dixylyldisulphide)
- Physical state: Liquid
- Analytical purity: Approximately 100%
- Purity test date: 04/07/1995
- Lot/batch No.: SMD95/14
- Expiration date of the lot/batch: 6th Jan 1996
- Storage condition of test material: Room temperature in the dark
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.1ml - Observation period (in vivo):
- 21 days after instillation
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not reported
SCORING SYSTEM:
Cornea (degree of density) , Iris (reaction to light) and Conjunctivae (redness and chemosis) were observed. The scoring system is summarised below .
Results and discussion
In vitro
Results
- Irritation parameter:
- cornea opacity score
- Value:
- <= 1
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24 - 72 hours
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24 -72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 -72 hours
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24 - 72 hours
- Score:
- ca. 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24 -72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24 - 72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24 - 72 hours
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24 - 72 hours
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
Any other information on results incl. tables
The results are tabulated below:
Rabbit Number and Sex |
Region of the Eye |
One Hour |
Day after Instillation |
|||||||
1 |
2 |
3 |
4 |
7 |
14 |
21 |
||||
3529 M |
Cornea |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Chemosis |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
3530 M |
Cornea |
|
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Iris |
|
0 |
0 |
0 |
0 |
0 |
0 |
|||
Conjunctivae |
Redness |
1 |
1 |
0 |
0 |
0 |
0 |
|||
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Instillation of DXDS into the rabbit eye produced mild transient conjunctival irritation in both animals. The persistent corneal opacity in one animal was not considered to be treatment related.
Based on the results of the study, classification for irritation to eyes in accordance with Regulation No. 1272/2008 is not required. - Executive summary:
A non-GLP study was performed to assess the effect of DXDS on the eye. 0.1ml of test substance was instilled into the eyes of two New Zealand White Rabbits. Observations were recorded for a maximum of 21 days after treatment. Mild transient conjunctivae irritation was observed in both animals, maximum score 2, the effects were reversible within 48 hours of instillation. One animal was noted to display mild corneal opacity with a 'scratch like' appearance, this was considered atypical and not treatment related.
The substance is considered to be mildly irritating to eyes but the requirements for classification are not met, therefore no classification with respect to eye irritancy is required.
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