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EC number: 261-645-3 | CAS number: 59185-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Justification for Read Across is given in Section 13 of IUCLID.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 2 doses were used but one dose only with males and females
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- EC Number:
- 239-622-4
- EC Name:
- 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- Cas Number:
- 15571-58-1
- Molecular formula:
- C36H72O4S2Sn
- IUPAC Name:
- 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecan-1-oate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 190-215 g.
- Fasting period before study: rats fasted overnight.
- Housing: in groups of 5.
- Diet: ad libitum.
- Water: ad libitum.
- Acclimation period: at least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 2 °C
- Humidity: 55 ± 10 %.
- Photoperiod: 12 hrs light/day
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 0.5 % (w/v) CMC in 0.1 % (w/v) polysorbate-80 (aq.)
- Details on oral exposure:
- DOSE VOLUME APPLIED: 10 ml/kg bw
- Doses:
- 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 1000 mg/kg bw: 5 males
2000 mg/kg bw: 5 males, 5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations: once or twice daily for clinical signs of toxicity and mortality.
- Frequency of weighing: on days 1 (prior to dosing), 7, 14, or at death.
- Necropsy of survivors performed: yes. Animals that died were sacrificed and necropsied. Surviving animals were sacrificed and necropsied at the end of the exposure period. - Statistics:
- Mortality data were evaluated and the LD50 (with lower 95 % confidence limit) was calculated by the logit model.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- < 2 000 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Mortality (number dead/total number exposed), by sex and concentration tested:
1000 mg/kg bw: 0/5 (males only)
2000 mg/kg bw: 1/5 male (died day 9), 4/5 females (died days 9, 10, 12, 13) - Clinical signs:
- Animals in both dose groups exhibited clinical signs of toxicity that included slight to moderate piloerection, dyspnea, hunched posture, and reduced locomotor activity. A single male in the 2000 mg/kg bw dose group exhibited signs of ataxia and cyanosis; all 5 females in that group also showed signs of ataxia. Surviving animals recovered within 6-13 days.
- Gross pathology:
- No substance-related gross organ changes were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: classified in Acute Toxicity Category 4 according to the CLP Regulation (EC) No.1272/2008.
- Conclusions:
- LD50 (rat) = 2000 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test material to rat was evaluated in the standard acute method according to the OECD Guideline 401. The substance was orally single administered to 5 males at 1000 mg/kg bw and to 5 male and 5 female rats at 2000 mg/kg bw. The rats were weighed on days 1 prior to dosing and then on day 7, 14 or at death. The rats were observed for 14 days for clinical signs of toxicity and mortality. Animals that died were sacrificed and necropsied. Surviving animals were sacrificed and necropsied at the end of the exposure period.
Animals in both dose groups exhibited clinical signs of toxicity and effects on mortality were observed.
LD50 < 2000 mg/kg bw (female rats)
LD50 > 2000 mg/kg bw (male rats)
overall LD50 was 2000 mg/kg bw
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