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Diss Factsheets
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EC number: 203-385-5 | CAS number: 106-32-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-10-21 to 2016-10-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 35.5 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 5.6
- Remarks on result:
- other: Mean of 6 measurements performed after 24h, 48h and 72h incubation
- Conclusions:
- The test item was found to have a water solubility of 35.5 mg/L at pH 5.6 and at 20°C.
- Executive summary:
The water solubility of the test substance was determined according to OECD test guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6.
The solubility of the test substance was determined using the flask method at 20 +/- 0.5 °C with pre-incubation at 30 +/- 0.5°C. Measurements were performed after 24, 48 and 72h pre-incubation.
The water solubility of the test substance was determined to be 35.5 mg/L (20°C, pH 5.6).
Reference
1. Preliminary test (non-GLP):
The determination solubility in double distilled water was in the range of 11.3 - 113 mg/L. For the application dose for the definitive study, 1 g/L, as ca. approximately the tenfold of the maximum solubility result, was used.
2. Method validation:
- Detection limits: LOD = 50 pg/L
- Linearity: linear response in the range of nominal 0.05 - 1.5 µg/L with r2 > 0.992
- Limit of quantification: LOQ = 7.5 mg/L
- Accuracy: mean recovery rates of 91% at 1 x LOQ and 99% at 4 x LOQ
- Precision: coefficient of determination between 5.4 and 11%
- Specificity: identity of test item signals demonstrated by automatic comparisson of sample peaks against spectra obtained from standard peaks.
- Check of Tyndall-Effect: negative in all replicates and at all time points
3. Water solubility results;
Water solubility has been measured at 20°C:
Preincubation time | Replicate No. | Test substance | |
Concentration (mg/L)* | Mean | ||
24 h | 1 | 33.5 | 41.0*** |
2 | 48.4 | ||
48h | 1 | 35.2 | 37.3 |
2 | 39.4 | ||
72h | 1 | 35.4 | 33.7 |
2 | 32.0 | ||
Mean (24-72h) | 35.5 | ||
Deviation (%) (24-72h)** | 10.7 |
* Mean value of double injection, dilution factor of 50000 and exact weights taken into account
** Calculated according to formula deviation [%]= 100x(max value-min value) / min value
*** Not taken into consideration due to instable results.
pH value: 5.6
4. Validation
The concentration measured in at least the samples with the two longest incubation times (48 and 72h) should not differ by more than 15%.
Temperatures: Temperatures should be kept constant within +- 0.5°C
Description of key information
For this endpoint, water solubility was determined experimentally according to OECD 105, flask method. The test item was found to have a water solubility of 35.5 mg/L at 20°C (pH 5.6)
Key value for chemical safety assessment
- Water solubility:
- 35.5 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.