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EC number: 237-860-3 | CAS number: 14024-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Anderson BS, Hunt JW, Turpen SL, Coulon AR, Martin M, McKeown DL & Palmer FH (1990) Procedures manual for conducting toxicity tests developed by the Marine Bioassay Project. 90-10WQ. State Water Resources Control Board, Sacramento, CA, USA.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- Zinc in filtered sea water from Granite Canyon, California, USA.
- Test organisms (species):
- other aquatic mollusc: Haliotis rufescens, Red Abalone, Haliotidae
- Details on test organisms:
- Origin of test organism: broodstock from Granite Canyon, California, USA; spawning induced in lab
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 10 d
- Test temperature:
- 15°C
- pH:
- pH met acceptability criteria
- Dissolved oxygen:
- Salinity=ambient; met acceptability criteria
- Nominal and measured concentrations:
- Nominal concentrations, but chemically verified
- Details on test conditions:
- Filtered sea water from Granite Canyon, California, USA
- Key result
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- zinc
- Basis for effect:
- other: development
- Details on results:
- Dose-response: EC50 reported
Analytically measured zinc concentrations were found to be close to nominal concentrations (coefficient of variation =17%). - Validity criteria fulfilled:
- yes
- Conclusions:
- Study relevant for PNEC derivation. The 10d-NOEC Development is the most sensitive endpoint for this species.
- Executive summary:
Experiments were conducted to compare a short-term 48-h aquatic toxicity test endpoint of abnormal larval shell development with other, more clearly adverse effects. In similar experiments conducted with zinc sulfate, red abalone (Haliotis rufescens) embryos were simultaneously exposed to identical dilution series and incubated for three different exposure periods: 48 h, 48 h followed by an 8-d recovery period in clean seawater, and 10 d of continuous exposure. Abnormal larval shell development was assessed in the 48-h short-term tests, and inhibition of metamorphosis was assessed in the exposure– recovery and continuous exposure experiments. For the zinc experiments, the median effective concentration (EC50) values for the 48-h exposure, the exposure–recovery experiment, and the continuous exposure experiment were 40, 34, and 32 mg/L zinc, respectively. Results indicate that toxicant concentrations causing abnormal larval shell development also inhibit metamorphosis and that larvae exposed to toxicant concentrations which inhibit larval shell development do not recover to metamorphose when transferred to clean seawater. None of the successfully metamorphosed postlarvae had deformed larval shells, indicating that shell deformity precludes survival past the planktonic stage. A longer (15-d) experiment allowed measurement of postlarval shell length in exposed postmetamorphic abalone. Insignificant differences in postlarval shell length indicated that the timing of larval metamorphosis was similar regardless of toxicant exposure and that the effects of the toxicant was to inhibit rather than to delay metamorphosis.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For long-time toxicity a dissociation of bis(pentane-2,4-dionato)zinc can be assumed.
By comparison of all ecotoxicity study resultes of bis(pentane-2,4-dionato)zinc to those of pentane-2,4-dione it can be assumed that the toxicity of the test material is determined only by the zinc moiety. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Anderson BS, Hunt JW, Turpen SL, Coulon AR, Martin M, McKeown DL & Palmer FH (1990) Procedures manual for conducting toxicity tests developed by the Marine Bioassay Project. 90-10WQ. State Water Resources Control Board, Sacramento, CA, USA.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- Zinc in filtered sea water from Granite Canyon, California, USA.
- Test organisms (species):
- other aquatic mollusc: Haliotis rufescens, Red Abalone, Haliotidae
- Details on test organisms:
- Origin of test organism: broodstock from Granite Canyon, California, USA; spawning induced in lab
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 10 d
- Test temperature:
- 15°C
- pH:
- pH met acceptability criteria
- Dissolved oxygen:
- Salinity=ambient; met acceptability criteria
- Nominal and measured concentrations:
- Nominal concentrations, but chemically verified
- Details on test conditions:
- Filtered sea water from Granite Canyon, California, USA
- Key result
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- zinc
- Basis for effect:
- other: development
- Key result
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 40 µg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat. (total fraction)
- Remarks:
- recalculated for bis(pentane-2,4-dionato)zinc based on the value for dissolved zinc
- Basis for effect:
- other: development
- Details on results:
- Dose-response: EC50 reported
Analytically measured zinc concentrations were found to be close to nominal concentrations (coefficient of variation =17%). - Validity criteria fulfilled:
- yes
- Conclusions:
- Study relevant for PNEC derivation. The 10d-NOEC Development is the most sensitive endpoint for this species.
The NOEC recalculated for bis(pentane-2,4-dionato)zinc is 263.6 g mol-1 / 65.4 g mol-1 x 10 µg/L = 40 µg/L
Endpoint (NOEC=40µg/L) was taken forward for PNEC derivation. - Executive summary:
Experiments were conducted to compare a short-term 48-h aquatic toxicity test endpoint of abnormal larval shell development with other, more clearly adverse effects. In similar experiments conducted with zinc sulfate, red abalone (Haliotis rufescens) embryos were simultaneously exposed to identical dilution series and incubated for three different exposure periods: 48 h, 48 h followed by an 8-d recovery period in clean seawater, and 10 d of continuous exposure. Abnormal larval shell development was assessed in the 48-h short-term tests, and inhibition of metamorphosis was assessed in the exposure– recovery and continuous exposure experiments. For the zinc experiments, the median effective concentration (EC50) values for the 48-h exposure, the exposure–recovery experiment, and the continuous exposure experiment were 40, 34, and 32 mg/L zinc, respectively. Results indicate that toxicant concentrations causing abnormal larval shell development also inhibit metamorphosis and that larvae exposed to toxicant concentrations which inhibit larval shell development do not recover to metamorphose when transferred to clean seawater. None of the successfully metamorphosed postlarvae had deformed larval shells, indicating that shell deformity precludes survival past the planktonic stage. A longer (15-d) experiment allowed measurement of postlarval shell length in exposed postmetamorphic abalone. Insignificant differences in postlarval shell length indicated that the timing of larval metamorphosis was similar regardless of toxicant exposure and that the effects of the toxicant was to inhibit rather than to delay metamorphosis.
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 40 µg/L
Additional information
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