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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 24088
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Stable at room temperature
- Solubility and stability of the test substance in the solvent/vehicle: Soluble and stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dilution in water
- Final dilution of a dissolved solid, stock liquid or gel: 0.04, 0.08, 0.12, 0.18, and 0.30 mg/L
OTHER SPECIFICS: Purity of test material was 14.17% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Nominal (mg CMIT/MIT per liter) 0.0 (control), 0.04, 0.08, 0.12, 0.18, and 0.30
- Sampling method: TS sampling intervals: 0 and 48 h.
- Sample storage conditions before analysis: Test samples were stored in 40 mL glass bottles at 2-4 ºC and analyzed within 48 hours. - Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnid
- Strain: Daphnia magna
- Source: In-house daphnid culture; Primary culture obtained from Aquatic Research Organisms division of Resource Analysts, Inc.
- Age at study initiation (mean and range, SD): First instar daphnids (< 24 h old)
- Feeding during test: No - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 40-48 mg/L (as CaCO3)
- Test temperature:
- 20.0 ± 1°C (20.2 to 20.9°C)
- pH:
- 8.0
- Dissolved oxygen:
- 60 – 105 % of saturation, 9.1 to 9.3 mg/L
- Salinity:
- Not applicable
- Conductivity:
- 1300 to 1400 µMhos/cm
- Nominal and measured concentrations:
- Nominal (mg CMIT/MIT per liter): 0.0 (control), 0.04, 0.08, 0.12, 0.18, and 0.30
Measured concentrations (mg CMIT/MIT per liter)
0 h 48 h Mean
0.05 0.05 0.05
0.08 0.08 0.08
0.12 0.12 0.12
0.19 0.18 0.18
0.31 0.30 0.30
The test substance was not detected in the control (analytical detection limit = 0.002 mg CMIT/MIT per liter). - Details on test conditions:
- TEST SYSTEM
- Test vessel: Flow-through
- Material, size, headspace, fill volume: 19.6 liter glass aquaria containing 15 liter of test solution
- Aeration: Yes
- Type of flow-through (e.g. peristaltic or proportional diluter): Intermittent flow proportional diluter
- Renewal rate of test solution (frequency/flow rate): During the test the diluter was activated 424 times resulting in an average of 7.1 media exchanges per 24 hours.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Filtered well water collected at Hampton, New Hampshire, USA
- Alkalinity: 154-190 mg/L (as CaCO3)
- Culture medium different from test medium: No
OTHER TEST CONDITIONS
- Adjustment of pH: Not described
- Photoperiod: 16 h daylight, 8 h darkness
- Light intensity: 10 µEs-1m-2
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.18 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 0.12-0.30
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.16 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0.14-0.19
- Details on results:
- - Mortality of control: 95 % survival occurred in the controls.
- Reported statistics and error estimates:
- Probit, moving average or binomial methods were used to calculate the 24 and 48 hour median EC50 and LC50 using computer methods (Stephan C.E., 1983, Computer program for calculation of LC50, values. US EPA, Duluth, Minnesota, USA, personal communication).
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results of this study, a 48-h EC50 of 0.16 mg/L was determined.
- Executive summary:
The 48 h NOEC was 0.12 mg CMIT/MIT per liter. No insoluble material was observed in any test vessel during the test.
LC50 48h = 0.18 mg CMIT/MIT per liter
EC50 48h = 0.16 mg CMIT/MIT per liter
Reference
Description of key information
The results of the key study indicated that acute exposure of Daphnia magna to CMIT/MIT resulted in an EC50 of 0.16 mg/L a.i.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.16 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 0.282 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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