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EC number: 294-589-3 | CAS number: 91744-27-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation in vivo (intracutaneous test) with a read-across substance: Negative
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No information is available for the substance itself, therefore information is derived from the structural analogue CAS 8001 -27 -3
Skin sensitisation in vivo (intracutaneous test) with CAS 8001-27-3
The skin sensitisation potential of the test substance was evaluated in a pre-guideline intracutaneous test in albino guinea pigs. A group of 8 animals was treated with 0.1% test compound and a positive control group of 4 animals was treated with the known sensitizer 2,4-dinitro-1-chloro benzene also at 0.1%. During the induction phase, the control or test compound, dissolved in physiological saline was injected every other day, three times each week until a total of 10 doses has been given. The injection sites were read and scored for diameter and intensity of erythema and height of edema at 24 and 48 hours following each injection. Two weeks after the administration of the tenth sensitization dose, a challenge dose was given by injection. Reactions were read and scored at 24 and 48 hours. When a score for a challenge dose was greater than the average score of the 10 sensitizing doses, the substance was considered to have produced dermal sensitization in the guinea pig. In two of the test animals, the challenge with the test substance resulted in slightly more erythema than the average of the 10 sensitizing doses. The challenge doses of the control compound produced a much greater reaction in all animals. It was therefore concluded that, under the conditions of the test, the substance is not considered to be sensitising, although it might produce sensitization in an unusually sensitive individual (International research and development corporation, 1964).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, the classifcation for skin sensitisation is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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