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Diss Factsheets
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EC number: 277-962-5 | CAS number: 74665-14-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature reference
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- Non occlusive application. Each animal was treated simulteneously at 4 application sites. 2 substances was tested at different concentrations on one animal in order to reduce the risk of any synergistic effects. Four hours exposure
- GLP compliance:
- no
Test material
- Reference substance name:
- Toluene sulphonic acid
- IUPAC Name:
- Toluene sulphonic acid
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- PTSA monohydrate 0.5-60% aqueous solutions
- Duration of treatment / exposure:
- 4 hours
- Details on study design:
- Non occlusive application. Each animal was treated simulteneously at 4 application sites. 2 substances was tested at different concentrations on one animal in order to reduce the risk of any synergistic effects. In the case of PTSA, the animals were exposed parallely to ethylene diamine, hydrofluoric acid, morpholine, sodium bifluoride, sodium hypochloride or propionic acid.
Results and discussion
In vivo
Results
- Remarks on result:
- other: not available
- Irritant / corrosive response data:
- Four hours exposure to 0.5% PTSA solution only caused irritation in one of three animals, while concentrations of 20-60% caused necrosis with subsequent scar formation
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Conclusions:
- Four hours exposure to 0.5% PTSA solution only caused irritation in one of three animals, while concentrations of 20-60% caused necrosis with subsequent scar formation
- Executive summary:
Non occlusive application. Each animal was treated simulteneously at 4 application sites. 2 substances was tested at different concentrations on one animal in order to reduce the risk of any synergistic effects. In the case of PTSA, the animals were exposed parallely to ethylene diamine, hydrofluoric acid, morpholine, sodium bifluoride, sodium hypochloride or propionic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.