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EC number: 241-143-0 | CAS number: 17084-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-03-26 to 2016-03-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 2008
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Potassium hexafluorophosphate
- EC Number:
- 241-143-0
- EC Name:
- Potassium hexafluorophosphate
- Cas Number:
- 17084-13-8
- Molecular formula:
- F6P.K
- IUPAC Name:
- potassium hexafluoro-λ⁵-phosphanuide
- Test material form:
- solid: crystalline
- Details on test material:
- - State of aggregation: solid
- Other: crystalline powder,
Colour: white
hygroscopic
Constituent 1
- Specific details on test material used for the study:
- Appearance: white crystalline powder
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
At the start of the exposure (0 hours), sampling was carried out after preparation of the limit concentration.
At the end of the exposure (48 hours), samples were taken from additional replicates, which were prepared with test media, but without daphnids.
These additional replicates were incubated under test conditions until sampling.
method validation:
The fortified samples for the 1 x LOQ level were analysed directly
after preparation. The 20 x LOQ level was diluted factor 10 with
HPLC water prior to analysis. The blank samples were used as blank
solution for spectrophotometric analysis.
- Sampling method:
All samples were prepared as described in the test kit manual.
The limit test concentration was diluted factor 10 with HPLC water
prior to analysis. The control was used as blank solution.
- Sample storage conditions before analysis:
All original samples were stored at 6 ± 2 °C. Prepared samples were
stored at room temperature until analysis, if necessary.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:
The limit concentration (100 mg/L of the test item were weighed out) was freshly prepared with dilution water (Elendt M4 medium as specified in Table 2) before the start of the exposure (at O hours).The limit concentration was mixed thoroughly by manual agitation.
- Evidence of undissolved material (e.g. precipitate, surface film, etc.):
not reported; soluble in accordance with water solubility
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS
- Strain/clone: (Clone 5)
- Justification for species other than prescribed by test guideline:
- Source:
origin: Institut für Wasser-, Boden- und Lufthygiene (WaBoLu), 14195 Berlin, Germany
breeder: Noack Laboratorien GmbH Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany
- Age of parental stock (mean and range, SD):
- Feeding during test
no
- Food type:
- Amount:
- Frequency:
ACCLIMATION
Acclimatisation of the daphnids was not necessary, because the dilution water was equivalent to the culture medium.
- Acclimation period:
- Acclimation conditions (same as test or not):
- Type and amount of food:
- Feeding frequency:
- Health during acclimation (any mortality observed):
QUARANTINE (wild caught)
- Duration:
- Health/mortality:
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES:
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- 178 mg CaCO3 / L20.3
- Test temperature:
- 20.3 °C
- pH:
- start: 8.83
end: 7.60 - 7.65 - Dissolved oxygen:
- start: 9.95
end: 7.37 - 7.82 - Salinity:
- (freshwater)
- Conductivity:
- 478 µS/cm
- Nominal and measured concentrations:
- nominal: 100 mg/L
measured:
start: 98.4, 98 mg/L
end (48h): 88.6, 89 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
Glass beakers (4 (ID) x 7 (H) cm), 50 mL capacity, loosely covered with watch glasses
- Material, size, headspace, fill volume:
test volume 20ml
- Aeration:
- Type of flow-through (e.g. peristaltic or proportional diluter):
static
- Renewal rate of test solution (frequency/flow rate):
static
- No. of organisms per vessel:
5
- No. of vessels per concentration (replicates):
3
- No. of vessels per control (replicates):
1
- No. of vessels per vehicle control (replicates):
no vehicle
- Biomass loading rate:
not reported
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
Composition of the Culture Medium Elendt M4 according to OECD 202, Annex 3 (2004)
other parameters see "test conditions"
- Culture medium different from test medium:
no
- Intervals of water quality measurement:
start and end of test
OTHER TEST CONDITIONS
- Adjustment of pH:
pH: see test "pH", adjustment not reported
- Photoperiod:
16 hours illumination,
- Light intensity:
light intensity of max. 20 pE•m-2 • s-1 (max. 1340 lx)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
immobilisation observation
VEHICLE CONTROL PERFORMED: yes/no
no vehicle
RANGE-FINDING STUDY
- Test concentrations:
1, 10, 100 mg/l, 48 h
- Results used to determine the conditions for the definitive study:
no immobilisation at all concentrations - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate p.a. (SIGMA)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Remarks:
- limit test
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: measurement based on nominal which was analytically confirmed (<20%deviation)
- Results with reference substance (positive control):
- The percentage of immobility for the reference item was determined after 24 hours. The EC50-value with 95% confidence limits (Cl) was calculated by sigmoidal dose-response regression. The EC50-value for the most recent of the monthly performed reference tests was:
EC50: 1.95 mg/L (Cl: 1.14 - 3.30 mg/L)
The EC50-value of the reference item potassium dichromate after 24 hours is within the required concentration range of 0.6 - 2.4 mg/L of quality criteria according to AQS P 9/2 (02/2000) for daphnids clone 5 cultured in Elendt M4 medium. The ECso-value of the reference item is also within the recommended range of 0.6 - 2.1 mg/L according to OECD-Guideline 202.
Any other information on results incl. tables
The percentage of immobility, determined in the limit concentration and in the control after 24 and 48 hours under static conditions, is given.
Immobilisation Rates after 24 and 48 hours of Exposure in the Definitive Test (n = 20,divided into 4 replicates with 5 daphnids each)
Nominal [mg/L] |
IMMOBILISATION [%] |
|||||||||
24 hours |
48 hours |
|||||||||
Replicates |
Replicates |
|||||||||
1 |
2 |
3 |
4 |
MV |
1 |
2 |
3 |
4 |
MV |
|
100 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
In
the limit concentration 100 mg/L of the test item PU-2015-627,
no effects onDaphnia magnawere observed.
EC10-, EC50- and EC100-Values
(based on the nominal concentration of the test item)
Effect levels |
Test |
Toxicity endpoint based on the nominal concentration the test item [mgiL] |
EC10/50 / 100 |
24 |
> 100 |
48 |
> 100 |
The study was performed according to OECD Guideline 202 (2004), which is equivalent to the Council Regulation (EC) No.440/2008 Method C.2 (2008).
The validity criteria were fulfilled:
In the control group, no daphnids were immobilised or showed any signs of disease or stress, e.g. discoloration or unusual behaviour such as trapping on the surface of the water, during the 48-hour test period (required: not more than 10% of the daphnids in the control).
The dissolved 02 concentration at the end of the exposure period was k 7.37 mg/L (required: k 3 mg/L) in the test vessels of the limit concentration and the control.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No effects on daphnia after 48h were observed at the limit concentration of 100 mg/L.
- Executive summary:
Potassium hexafluorophosphate effects on daphnia acute were tested according to OECD 202 for 48 hours in a limit test with analytical confirmation.
No effects on daphnia after 48h were observed at the limit concentration of 100 mg/L.
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