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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
To assess the acute inhalation toxicity of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) extrapolation calculations were performed.
GLP compliance:
no
Test type:
other: extrapolation calculation
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(2-hydroxyethyl)-p-phenylenediammonium sulphate
EC Number:
298-995-1
EC Name:
3-(2-hydroxyethyl)-p-phenylenediammonium sulphate
Cas Number:
93841-25-9
Molecular formula:
C8H12N2O.H2O4S
IUPAC Name:
2-(2,5-Diaminophenyl)ethanol sulfate (1:1)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1.13 mg/L air
Based on:
other: extrapolation calculation
Exp. duration:
4 h

Any other information on results incl. tables

Calculations :

Maximum volume of exposure in 4 hours :

0.074 L/min x 60 min x 4 hour = 17.76 litres

Maximum achievable exposure regarding required 5 mg/L for 4 hours (OECD 403)

17.76 x 5 mg/L = 88.8 mg/rat

88.8 mg/0.25kg bw = 355 mg/kg maximum achievable exposure

Inhalation bioavailability : 100% (assumed)

Correction factor oral vsinhalation route : 1.00

LC50 calc inhalation = 80 x 0.25 x 1.00/17.76 = 1.13 mg/L

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Based on the available acute oral toxicity and kinetic data, the LD50 value for acute inhalation toxicity of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) was calculated to be 1.13 mg/L. The substance is classified as Acute Tox. Cat 4; H332 harmful if inhaled according to CLP (GHS) criteria.
Executive summary:

The determination of acute inhalation toxicity was performed by calculation using the available acute oral toxicity and kinetic data. The bioavailability of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) via the inhalation route is assumed to be 100% (equivalent to oral bioavailability). The LD50 value for acute inhalation toxicity of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) was calculated to be 1.13 mg/L.The substance is classified as Acute Tox. Cat 4; H332 harmful if inhaled according to CLP (GHS) criteria.