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Diss Factsheets
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EC number: 298-995-1 | CAS number: 93841-25-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- To assess the acute inhalation toxicity of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) extrapolation calculations were performed.
- GLP compliance:
- no
- Test type:
- other: extrapolation calculation
- Limit test:
- no
Test material
- Reference substance name:
- 3-(2-hydroxyethyl)-p-phenylenediammonium sulphate
- EC Number:
- 298-995-1
- EC Name:
- 3-(2-hydroxyethyl)-p-phenylenediammonium sulphate
- Cas Number:
- 93841-25-9
- Molecular formula:
- C8H12N2O.H2O4S
- IUPAC Name:
- 2-(2,5-Diaminophenyl)ethanol sulfate (1:1)
Constituent 1
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 1.13 mg/L air
- Based on:
- other: extrapolation calculation
- Exp. duration:
- 4 h
Any other information on results incl. tables
Calculations :
Maximum volume of exposure in 4 hours :
0.074 L/min x 60 min x 4 hour = 17.76 litres
Maximum achievable exposure regarding required 5 mg/L for 4 hours (OECD 403)
17.76 x 5 mg/L = 88.8 mg/rat
88.8 mg/0.25kg bw = 355 mg/kg maximum achievable exposure
Inhalation bioavailability : 100% (assumed)
Correction factor oral vsinhalation route : 1.00
LC50 calc inhalation = 80 x 0.25 x 1.00/17.76 = 1.13 mg/L
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the available acute oral toxicity and kinetic data, the LD50 value for acute inhalation toxicity of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) was calculated to be 1.13 mg/L. The substance is classified as Acute Tox. Cat 4; H332 harmful if inhaled according to CLP (GHS) criteria.
- Executive summary:
The determination of acute inhalation toxicity was performed by calculation using the available acute oral toxicity and kinetic data. The bioavailability of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) via the inhalation route is assumed to be 100% (equivalent to oral bioavailability). The LD50 value for acute inhalation toxicity of 2-(2,5-diaminophenyl)ethanol sulphate (3-(2-hydroxyethyl)-p-phenylenediammonium sulphate) was calculated to be 1.13 mg/L.The substance is classified as Acute Tox. Cat 4; H332 harmful if inhaled according to CLP (GHS) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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