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EC number: 264-935-8 | CAS number: 64519-44-4
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 August 2017 - 18 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study has been conducted according to OECD/EU guideline and under GLP. No significant deviation is reported. The substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009 Method A.4: “Vapour Pressure”
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP certificate (inspected on 15 to 16 November 2017 / signed on 15 May 2018)
- Type of method:
- effusion method: Knudsen cell
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.001 Pa
- Remarks on result:
- other:
- Remarks:
- extrapolated from the regression
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other:
- Remarks:
- extrapolated from the regression
- Conclusions:
- Low volatility.
- Executive summary:
The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, effusion method (Knudsen cell). Determinations were conducted at 30, 45, 60, 75, 90 and 105 °C. Experiment 1 (nominal temperature 30 °C) showed no reproducible weight loss. These measurements were not used for calculations.
The other temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P): the graph shows a straight line with a correlation coefficient (r) of -0.9934.
Vapour pressure at 20 and 25 °C was extrapolated from the regression.
The vapour pressure of the test item has been determined to be 0.000424 Pa at 20°C and 0.000744 Pa at 25 °C.
Reference
The mass of sample used in the respective cell, the data of the evaluated experiments and calculation results were reported in the report.
Note that Experiment 1 (nominal temperature 30 °C) showed no reproducible weight loss. Therefore these values were not used for calculations.
After the third measurement of 105 °C the determination was finished as enough values were given and the cells were nearly empty.
A summary of the mean of all measured values for temperature and vapour pressure is reported below :
Table 4.6/1: Vapour pressure results, in Pa
| T | T | p | Stand, Dev, p | RSD p |
| °C | K | Pa | Pa | % |
| 45 | 318,2 | 7,63E-03 | 1,52E-03 | 19,90% |
| 60 | 333,2 | 1,96E-02 | 5,67E-03 | 29,00% |
| 75 | 348,2 | 6,56E-02 | 3,85E-03 | 5,90% |
| 90 | 363,2 | 2,75E-01 | 1,79E-02 | 6,50% |
| 105 | 378,2 | 9,52E-01 | 1,81E-02 | 1,90% |
These measured values were evaluated as follows:
Table 4.6/2: Evaluation of the data:
Parameter |
T |
Mean p |
1/T |
log p |
Unit |
K (°C) |
Pa |
1/K |
log Pa |
|
318.2 K (45.0°C) |
7.63E-03 |
3.1427E-03 |
-2.1173 |
333.2 K (60.0°C) |
1.96E-02 |
3.0012E-03 |
-1.7079 |
|
348.2 K (75.0°C) |
6.56E-02 |
2.8719E-03 |
-1.1830 |
|
363.2 K (90.0°C) |
2.75E-01 |
2.7533E-03 |
-0.5606 |
|
378.2 K (105.0°C) |
9.52E-01 |
2.6441E-03 |
-0.0213 |
A graph with log P vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression:
slope = -4264.5
intercept = 11.1750
Correlation Coefficient r = -0.9934
Coefficient of Determination r2 = 0.9868
The linear regression of log P vs. 1/T gave a correlation coefficient r of -0.9934, showing good repeatability and precision. In addition, the vapour pressure measured for the positive control at 30°C met the validity criteria. Therefore, the determination is considered as valid.
Finally, the following vapour pressures at 20°C and at 25°C were calculated for the test item, from the regression equation (extrapolation):
Vapour pressure at 20°C: 0.000424 Pa
Vapour pressure at 25°C: 0.000744 Pa
Description of key information
Low volatility.
Key value for chemical safety assessment
- Vapour pressure:
- 0.001 Pa
- at the temperature of:
- 25 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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