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EC number: 264-355-5 | CAS number: 63589-47-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- INITIAL SUBMISSION:TOXICITY STUDY
- Author:
- National Technical Reports Library
- Year:
- 1 992
- Bibliographic source:
- INITIAL SUBMISSION
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute oral toxicity of Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methyltriphenylphosphonium bromide
- EC Number:
- 217-218-9
- EC Name:
- Methyltriphenylphosphonium bromide
- Cas Number:
- 1779-49-3
- Molecular formula:
- C19H18P.Br
- IUPAC Name:
- Methyltriphenylphosphonium bromide
- Details on test material:
- Name - Methyltriphenylphosphonium bromide
InChI: 1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
Smiles:[P+](c1ccccc1)(c1ccccc1)(c1ccccc1)C.[BrH-]
- Molecular formula (if other than submission substance):C19H18BrP
- Molecular weight (if other than submission substance):357.229 g/mole
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- Name - Methyltriphenylphosphonium bromide
InChI: 1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
Smiles:[P+](c1ccccc1)(c1ccccc1)(c1ccccc1)C.[BrH-]
- Molecular formula (if other than submission substance):C19H18BrP
- Molecular weight (if other than submission substance):357.229 g/mole
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% - Doses:
- Range of 50-800 mg/kg
- No. of animals per sex per dose:
- Total = 20
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: Animals were observed for mortality, clinical signs and body weight change. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- 118 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 84 - 167
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 118 mg/kg bw
- Clinical signs:
- other: Clinical signs were observed in treated rats. At 50 mg/kg symptoms like diarrhea was observed in 2-4 hr. which was normal within 24 hr. At 100 mg/kg symptoms like diarrhea was observed in 2-4 hr. At the range of 200-800 mg/kg: Tremors, convulsions, diar
- Gross pathology:
- not specified
- Other findings:
- not specified
Any other information on results incl. tables
Table: Acute oral toxicity of Methyltriphenylphosphonium Bromide
Solution |
Animals* No. and Species |
Route** |
Dose Range mg/kg |
Approx. LD50*** mg/kg |
Symptoms |
Time of death |
Weight change 2 wks |
Acute Toxicity 10% in H2O |
20R |
PO |
50-800 |
118 84-167 |
50 mg/kg: Sl. to mod. w., some diarrhea 2-4 hr., normal 24 hr. 100 mg/kg: Mod. to severe wk., diarrhea 2-4 hr. 200-800 mg/kg: Tremors, convulsions, diarrhea and death <24 hr. |
2.5-24 hr |
7+ |
*R= Rat
**PO= Orally
***NRC= No range calculable
Remarks: Moderately toxic to rats orally and highly toxic to mice orally.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 was considered to be approximately 118 mg/kg with confidential limit of 84-167mg/kg bw, when rats were treated with Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) via oral route.
- Executive summary:
The acute oral toxicity of Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) was tested in 20 rats at the dose concentration range of 50-800 mg/kg bw. The test substance was dissolved as 10% in water (Vehicle). Animals were observed for mortality, clinical signs and body weight change for 14 days. 50% mortality was observed within 2.5-24 hr at 118 mg/kg bw. Clinical signs were observed in treated rats. At 50 mg/kg symptoms like diarrhea was observed in 2-4 hr. which was normal within 24 hr, considered to be slightly to moderate; At 100 mg/kg symptoms like diarrhea was observed in 2-4 hr which was considered as moderate to severe; and At the range of 200-800 mg/kg: Tremors, convulsions, diarrhea and death within 24 hr was observed which was considered to be highly toxic. Weight change was observed in more than 7 rats. Therefore, LD50 was considered to be approximately 118 mg/kg with confidential limit of 84-167mg/kg bw, when rats were treated with Methyltriphenylphosphonium bromide via oral route.
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