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EC number: 209-527-2 | CAS number: 584-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38 412, Part 15, Determination of the Effect of Substances in Water on Fish (L15) (Fish-T est). German Institute for Standardization, Berlin. Version June 1982
- Version / remarks:
- June 1982
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Butane-1,2-diol
- EC Number:
- 209-527-2
- EC Name:
- Butane-1,2-diol
- Cas Number:
- 584-03-2
- Molecular formula:
- C4H10O2
- IUPAC Name:
- butane-1,2-diol
- Details on test material:
- - Name of test material (as cited in study report): 1,2-butanediol
- Physical state: liquid
- Test substance No.: 88/680
- Purtity: 99%
- Water solubility: miscible at any ratio
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The product was added to the test water without any pretreatment; subsequently the fish were placed in the aquaria.
Test organisms
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: golden orfe
- Consigment dated: Oct. 18, 1988
- Supplier/Breeder: Fischzucht Paul Eggers, D-2354 Hohenwestedt, Frg.
- Body length: 7.5 cm (range 6.9-7.9)
- Body weight: 3.6 g (range 2.8-4.6)
- Corpulence factor: 0.9
HOUSING:
- Keeping: Fish were kept in a flow-through tank in tap water cleaned by active carbon and aerated with oil-free air.
- Duration: about 4 months
- Temperature: 20 ± 1 °C
- Photoperiod: 16:8 day:night
- Total hardness: ca. 2.5 mmol/L
- Acid capacity: ca. 5.5 mmol/L
- Oxygen content: >60% of max. saturation
- pH: ca. 8
- Mortality during last week of housing: ca. 0.6%
- Mortality during adaptation period: 0%
- Medical treatment: 4 times with 0.05 mg/L malachite green chloride, 2 times with 10 mg/L tetracycli ne hydrochloride
- Diet: growing feed F/B 50 (SSNIFF Spezialdiaeten GMBH, D-4770 Soest, Frg); ad libitum
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5 mmol/L
- Test temperature:
- 21 °C
- pH:
- 7.3 - 7.9
- Dissolved oxygen:
- 6.8 - 8.6 mg/L
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control), 5000 and 10000 mg/L (based on range-finding test).
- Measured concentrations: no analysis performed. - Details on test conditions:
- STUDY DESIGN:
- Test vessel: All-glass aquarium (30x22x24 cm)
- Test volme: 10 L
- Number of animals per test conc.: 10
- Loading (g fish/L): 3.6
- Adaptation period: 3 days
- Photoperiod: 16:8 day:night
- Aeration: slight
- Withdrawal of feed: 1 day before the test.
TEST MEDIUM:
Reconstituted freshwater according to guideline. Preparation from fully demineralised tap water. Conductivity max. micro MHO
EFFECT PARAMETERS MEASURED:
Mortality and general symptoms of toxicity at 1, 4, 24, 48, 72 and 96 hours after the start of the test. - Reference substance (positive control):
- yes
- Remarks:
- chloracetamide
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Mortality: At the 10000 mg/L test group 2/10 deaths were recorded, 24 hours after the start of the test.
Symptoms: No symptoms of toxicity observed. - Results with reference substance (positive control):
- 48-h LC50: ca. 32 mg/L (determined Feb. 20, 1989)
- Reported statistics and error estimates:
- Finney, D.J., Probit Analysis, Cambr. Univ. Press, 3rd ed.., 1971 (modified).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
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