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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- They study was performed in accordance with generally accepted scientific principles and presented as a short abstract. There was adequate reporting of the methodology and results. Based on the available information the study can be considered reliable, but with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The irritation potential of the undiluted test material was determined using 3 rabbits. The clipped intact skin of each rabbit was exposed to the test material under an occlusive dressing for 24 hours. Animals were observed for signs of irritation for 7 days and scored in accordance with the Draize scale (1944).
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50
- Molecular formula:
- Not possible, UVCB
- IUPAC Name:
- Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- The test material was applied undiluted. - Duration of treatment / exposure:
- 24 hours.
- Observation period:
- 7 days
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Preparation of exposure area: The skin of each animal was clipped and left intact.
- Type of wrap if used: The treated area was covered with plastic strips.
REMOVAL OF TEST SUBSTANCE
- The patch ws removed after 24 hours.
SCORING SYSTEM: Draize scale (1944).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1.6
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1.3
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.6
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Following removal of the application, effects were reversible within 3 days in one animal and by day 5 in all others.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the test, slight to mild irritation was observed 24 hours after removal of the undiluted test material. This reaction was reversible in one animal after 3 days and after 5 days in the remaining two animals. The author of the report concludes that the test material is a mild irritant, however the recorded irritation was not sufficient for classification in accordance with CLP; the test material is therefore determined to be not irritating.
- Executive summary:
The irritation potential of the undiluted test material was determined using 3 rabbits. No guideline was followed. The clipped intact skin of each rabbit was exposed to the test material under an occlusive dressing for 24 hours. Animals were observed for signs of irritation for 7 days and scored in accordance with the Draize scale (1944).
Under the conditions of the test, slight to mild irritation was observed 24 hours after removal of the undiluted test material. This reaction was reversible in one animal after 3 days and after 5 days in the remaining two animals. The author of the report concludes that the test material is a slight to mild irritant, however, the recorded irritation was not sufficient for classification in accordance with CLP; the test material is therefore determined to be not irritating.
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