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EC number: 915-640-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The skin irritation test included topical application of the material to intact and abraded skin on the abdomen of two male New Zealand White
rabbits. Both application sites on one rabbit were moistened with 0.5 ml of water, while the material was applied under dry conditions on the
other rabbit. The rabbits received either three (abraded sites) or five (intact sites) daily 0.5 g applications. The animals were on study for
eight days. - GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]
- EC Number:
- 915-640-4
- Molecular formula:
- C22 H30 O7 S2 . 2 Na
- IUPAC Name:
- Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]
- Details on test material:
- Chemical Name : XU-40340.00. DOWFAX 3B2, Powder Form
Appearance: tan solid
Source: Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Two male rabbits were used for the skin irritation test.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- other: unchanged and moistened
- Controls:
- no
- Amount / concentration applied:
- 0.5 g,
Both application sites on one rabbit were moistened with 0.5 ml of water, while the material was applied under dry conditions on the
other rabbit. - Duration of treatment / exposure:
- The rabbits received either three (abraded sites) or five (intact sites) daily 0.5 g applications. The test material was left in place for 24 hours.
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- The skin irritation test included topical application of the material to intact and abraded skin on the abdomen of two male New Zealand White
rabbits. Both application sites on one rabbit were moistened with 0.5 ml of water, while the material was applied under dry conditions on the
other rabbit. The rabbits received either three (abraded sites) or five (intact sites) daily 0.5 g applications. The test material was applied under a cotton pad and held in place with a cloth bandage. The test material was left in place for 24 hours. The animals were on study for eight days.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72, 96 hours and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact abdomen- dry patch
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Abraded abdomen- dry patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48 and 72 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 96 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Intact abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 48 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Intact abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 and 96 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Intact abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72, and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact abdomen- wet patch
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: Abraded abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 48 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: Abraded abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: Abraded abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- wet patch
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- wet patch
- Irritant / corrosive response data:
- No irritation was observed when the test material was administered unmoistened (dry patch) to intact skin after prolonged and repeated contact. Slight to moderate erythema was observed after prolonged and repeated contact under moistened conditions (wet patch) and on the abraded site under unmoistened (dry patch)conditions. The dermal response was attributed to mechanical injury. The test material appeared to glue the cotton patch to the skin when moisture was present and removal of the patch was difficult. Results of the skin irritation test indicated the test material is unlikely to be absorbed in acutely toxic amounts.
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: Not categorized, irritation was a result of mechanical injury
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- No irritation was observed when the test material was administered unmoistened (dry patch) to intact skin after prolonged and repeated contact. Slight to moderate erythema was observed after prolonged and repeated contact under moistened conditions (wet patch) and on the abraded site under unmoistened (dry patch)conditions. The dermal response was attributed to mechanical injury. The test material appeared to glue the cotton patch to the skin when moisture was present and removal of the patch was difficult. Results of the skin irritation test indicated the test material is unlikely to be absorbed in acutely toxic amounts.
- Executive summary:
The test material, XU-40340.00 DOWFAX 3B2, powder form, was submitted by the Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company, Midland, MI. The material is of interest for use in the agriculture, cleaning, and textile industries. Standard acute toxicologic tests were conducted and included the acute oral toxicity, skin irritation, and eye irritation studies.
Topical application of the test material to the skin of a New Zealand White rabbit, under dry conditions, resulted in no irritation after prolonged and repeated contact. Slight to moderate- erythema was observed under moistened conditions after prolonged and repeated contact. The dermal response was attributed to mechanical injury. The test material appeared to glue the cotton patch to the skin when moisture was present and removal of the patch was difficult.
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