Registration Dossier
Registration Dossier
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EC number: 257-775-5 | CAS number: 52238-69-4
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
During the subacute repeated dose toxicity/reproductive toxicity tests available, no NOAEL could not be determined due to absence of adverse toxic effects at the highest tested concentration of 1000 mg/kg bw/day; therefore no Derived No Effect Levels for both inhalation and dermal long-term exposure, systemic effects, are estimated.
No DNEL is derived for inhalation acute exposure, systemic effects, based on the physical state of the substance, inhalation is not an appropriate route of exposure. In addition, no DNEL is derived for both long-term/acute local effects because significant exposure by inhalation route is unlikely to occur due to the physical state of the substance; the substance is not irritant for skin/eyes and an effect on mucous is not expected.
No DNEL is derived for dermal acute exposure, systemic effects, because no acute toxicity potential was observed up to 2000 mg/kg bw. Since no substance-related local effects were observed, no DNEL for long-term dermal local effects was derived. In addition, the substance is not skin irritating, therefore no hazard has been identified for local effects due to acute dermal exposure.
Also regarding the eye irritation potential, no hazard has been identified on the basis of the available investigations.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
During the subacute repeated dose toxicity/reproductive toxicity tests available, no NOAEL could not be determined due to absence of adverse toxic effects at the highest tested concentration of 1000 mg/kg bw/day; therefore no Derived No Effect Levels for inhalation, dermal and oral long-term exposure, systemic effects, are estimated.
No DNEL is derived for inhalation acute exposure, systemic effects, based on the physical state of the substance, inhalation is not an appropriate route of exposure. In addition, no DNEL is derived for both long-term/acute local effects because significant exposure by inhalation route is unlikely to occur due to the physical state of the substance; the substance is not irritant for skin/eyes and an effect on mucous is not expected.
No DNEL is derived for either oral or dermal acute exposure, systemic effects, because no acute toxicity potential was observed up to 5000 and 2000 mg/kg bw, respectively.
Since no substance-related local effects were observed, no DNEL for long-term dermal local effects was derived. In addition, the substance is not skin irritating, therefore no hazard has been identified for local effects due to acute dermal exposure.
Also regarding the eye irritation potential, no hazard has been identified on the basis of the available investigations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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