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EC number: 205-521-9 | CAS number: 142-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD-guideline 471. Study well documented, meets generally accepted scientific principles, acceptable for assesment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Non-mutagenicity of 27 aliphatic acrylate esters in the Salmonella-microsome test.
- Author:
- Waegemaekers THJM, Bensink MPM
- Year:
- 1 984
- Bibliographic source:
- Mutat. Res. 137: 95-102
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Method: standard procedure as described by Ames et al. (1975) Ames test
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- hexyl 2-methylprop-2-enoate
- EC Number:
- 205-521-9
- Cas Number:
- 142-09-6
- Molecular formula:
- C10H18O2
- IUPAC Name:
- hexyl 2-methylprop-2-enoate
- Test material form:
- liquid
- Details on test material:
- 2-Propenoic acid, 2-methyl, hexylester (CAS: 142-09-6)
Supplier: Polyscience Inc.
Purity: 97 %
Constituent 1
Method
- Target gene:
- his-
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA1535, TA1537, TA1538, TA98, TA100
- Metabolic activation:
- with and without
- Metabolic activation system:
- AROCLOR 1254 or phenobarbitone induced rat liver S9 mix.
- Test concentrations with justification for top dose:
- 40-25000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Controls
- Untreated negative controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- sodium azide
- benzo(a)pyrene
- other: 2-Aminoantracene
- Details on test system and experimental conditions:
- Salmonella typhimurium reverse mutation assay, Ames test
To minimise evaporation treated plates were sealed in glass air-tight exposure jars.
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium, other: TA1535, TA1537, TA1538, TA98, TA100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Using a valid scientific method, n-Hexyl methacrylate was negative for genotoxicity in the Salmonella typhimurium reverse mutation assay. - Executive summary:
The potential of n-hexyl methacrylate (n-HMA) to induce reverse mutation in Salmonella typhimurium (strains: TA 98, TA 100, TA 1535, TA 1537, TA1538) was evaluated on triplicate plates according to a protocol comparable to the OECD guidelines 471 (standard Ames assay, Waegermakers et al., 1984). n-hexyl methacrylate was tested with and without a metabolic activation system, according to the standard procedure as described by Ames et al. (1975). At least 4 concentrations up to 2500 µg/plate were tested. n-HMA was once tested with phenobarbial-induced S9 mix, once with Aroclor-1254 -induced S9 mix and twice without any additional metabolizing system. n-HMA was diluted in DMSO prior to use. Solvent controls, positive controls and sterility controls for S9 mix were run with each experiment. His+ (histidine dependent) colonies arising on plates were manually-counted after 48 to 72 h after incubation in the dark at 37 °C. The positive control chemicals induced a significant increase of the revertant frequency in all tester strains, either with or without metabolic activation. n-HMA was negative, in the presence and absence of metabolic activation, in all tester strains.
Using a valid scientific method, n-Hexyl methacrylate was negative for genotoxicity in the Salmonella typhimurium reverse mutation assay.
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