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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978-03-15 to 1978-04-27
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
Only two concentrations were tested.
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
EC Number:
255-527-0
EC Name:
Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
Cas Number:
41741-86-0
Molecular formula:
C34 H24 Cr N8 O6 .Na
IUPAC Name:
Sodium;chromium(3+);2-[(3-methyl-5-oxido-1-phenylpyrazol-4-yl)diazenyl]benzoate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Diet: ad libitum, HERILAN MRH-Haltung (single diet for housing of mice, rats and hamsters) from Heinrich EGGERSMANN KG, Rinteln
- Weight at study initiation (mean per animal):
* at 5000 mg/kg: 240 g (males), 190 g (females)
* at 2150 mg/kg: 250 g (males), 180 g (females)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 35 % and 21.5 % of test substance in 0.5 % aqueous CMC

MAXIMUM DOSE VOLUME APPLIED:
at 5000 mg/kg: 14.29 mL/kg (volume per animal: 3.43 mL to males, 2.71 mL to females)
at 2150 mg/kg: 10 mL/kg (volume per animal: 2.5 mL to males, 1.8 mL to females)
Doses:
2150 and 5000 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes (after end of trial on day 14)
- Other examinations performed: clinical signs (heart, liver, kidney, gonads, spleen, adrenal, thyroid, brain, tumour(s))

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No animal died during the study.
Clinical signs:
other: No clinical signs were observed.
Gross pathology:
No gross internal lesions were observed during necropsy.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met