1-ethoxy-2,3-difluorobenzene

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000-09-28 to 2000-10-04

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

OECD Guideline No. 105, adopted on
27th July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

EC Directive No. 92/69/EEC, A.6 of 31 July 1992

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Key result

Water solubility:

254 mg/L

Conc. based on:

test mat.

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

9

Details on results:

Preliminary test:
This test was performed at room temperature in vessels protected from light. The pH value of the water used was 7.13. The preliminary test indicated that the test substance was soluble in water with a solubility above 10 mg/L. On the basis of these results, the final solubility determination was undertaken using the flask method.
Flask method:
The test was performed at 20 ± 2 °C, in vessels protected from light. The solubility in water was found to be 254 ± 4 mg/L with a precision of 2 %. The water used had a pH value of 7.5. In the three replicate solutions prepared, the pH values were found to be, 9.00, 9.00 and 8.99 (replicates 1 to 3).

Replicate number	Water solubility at 20 °C (mg/L)
/ Sampling Time	First dilution	Second dilution	Mean (n=2)	Mean (n=6)
3 / T48h	254	259	257
2 / T72h	247	258	253
1 / T96h	252	255	254
				253
			SD	7.78
			CV %	3

Conclusions:

The water solubility of the test item was determined to be 254 mg/L at 20 °C and pH 9.

Executive summary:

The water solubility was determined according to Directive 92/69/EEC method A.6 and OECD Guideline No. 105, adopted on 27th July 1995 using the shake flask method with HPLC analysis. A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of Milli-Q water to the flasks, they were shaken at 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations were determined by HPLC. The water solubility of the test substance was determined to be 254 mg/L at 20 °C and pH = 9.

Description of key information

The water solubility of the test item was determined to be 254 mg/L at 20 °C and pH 9.

Key value for chemical safety assessment

Water solubility:

254 mg/L

at the temperature of:

20 °C

Additional information

The water solubility was determined according to Directive 92/69/EEC method A.6 and OECD Guideline No. 105, adopted on 27th July 1995 using the shake flask method with HPLC analysis. A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of Milli-Q water to the flasks, they were shaken at 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations were determined by HPLC. The water solubility of the test substance was determined to be 254 mg/L at 20 °C and pH = 9.