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Diss Factsheets
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EC number: 815-961-9 | CAS number: 1374760-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental dates: 2017-10-11 to 2017-10-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. No significant deviation was reported. The test substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- (2004)
- Deviations:
- yes
- Remarks:
- standards were injected separately instead of simultaneously
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24 (Partition coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method)
- Version / remarks:
- Regulation (EC) No.440/2008 (as updated by Regulation (EU) No.2016/266)
- Deviations:
- yes
- Remarks:
- standards were injected separately instead of simultaneously
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspection June 7th-10th,2016 and July 13th,2016. Signed Jan. 03rd, 2017.
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.4
- Temp.:
- 22.7 °C
- pH:
- ca. 4 - ca. 9
- Conclusions:
- The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
- Executive summary:
The partition coefficient of the test substance was measured under GLP according to the OECD 117/ EU A24 guideline, HPLC method.
The system was calibrated with 6 reference substances, between logKow 1.6 and 3.2, and the partition coefficient of the test substance was interpolated from the linear regression. All measurements were performed in duplicate.
The partition coefficient (log Kow) of the test substance has been determined to be 2.4 (at 22.7°C; no pH-dependency anticipated).
Reference
Details on the determination of dead time and calibration data of the reference items are provided in the study report.
The calculated slope, Y-intercept and correlation coefficient for the first and second calibration of the reference items are:
1st Calibration | 2nd Calibration | |
slope | 1.7585 | 1.7545 |
Y-intercept | 0.8088 | 0.8134 |
r2 | 0.9877 | 0.9876 |
r | 0.9938 | 0.9938 |
(Diphenylamine values were considered as outliers, and discarded. However, the total number of reference substances is still≥ 6, as required by the guideline. Therefore, the elimination of diphenylamine is not considered to affect the validity of the study.)
For the test item, the mean retention time was used to derive two individual logPow values under consideration of the first and second calibration. As the values were consistent (within 0.1 log unit), a mean value was calculated from these individual logPow values.
1st Calibration: 2.41 ± 0.03; 2.31 to 2.50 (95 % CI)
2nd Calibration: 2.41 ± 0.03; 2.31 to 2.50 (95 % CI)
Mean: 2.41
Description of key information
The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria. The substance has LOW potential for bioaccumulation (log Kow < 4).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.4
- at the temperature of:
- 22.7 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study, and the result is retained as key value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.