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Diss Factsheets
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EC number: 253-930-6 | CAS number: 38436-16-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 890 mg/kg bw, OECD Guideline 401, GLP compliant (Dow Corning Corporation, 1985).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 890 mg/kg bw
- Quality of whole database:
- The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
According to the integrated testing strategy, no data are required for acute toxicity due to the corrosive nature of [2-(perfluorobutyl)ethyl]dichloro(methyl)silane. Acute toxicity studies were already available for the substance and these are included in the dossier for completeness.
[2-(Perfluorobutyl)ethyl]dichloro(methyl)silane has been tested for acute oral toxicity according to OECD 401 and in compliance with GLP (Dow Corning Corporation, 1985). The study is considered to be reliability 2 because only two rats were treated per dose level, and the reporting is limited. Undiluted test material was administered by gavage to one male and one female rat per dose at 316, 630, 1260 and 2520 mg/kg bw. All animals administered 1260 and 2520 mg/kg bw died, the females on day 0 and the males on day 2. It is concluded that the LD50 is 890 mg/kg bw under the conditions of the test. This study was selected as key because, although it is of lower reliability and older than the other available study, it gives a more conservative estimate of the LD50.
A second acute oral toxicity study is available in which [2-(perfluorobutyl)ethyl]dichloro(methyl)silane was tested according to OECD 401 and in compliance with GLP (TNO, 1986). The test substance was diluted with maize oil prior to administration by gavage to six groups of 5 male and 5 female rats. Doses ranged from 2500 to 5190 mg/kg bw. Some rats at the lowest doses and all rats dosed with 3600 mg/kg bw lost consciousness within an hour of dosing. Later, clinical signs including coma were observed. No gross abnormalities were observed on autopsy of rats that died and of survivors. Animals that survived recovered gradually. Deaths occurred in all dose groups, and weight loss or growth retardation were observed in some rats. The LD50 was determined to be 2593 mg/kg bw.
Justification for classification or non-classification
[2-(Perfluorobutyl)ethyl]dichloro(methyl)silane is classified Acute Toxicity Category 4 - oral, with hazard statement H302: 'Harmful if swallowed' according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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