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EC number: 226-558-7 | CAS number: 5424-01-1
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 February 2013 - 28 March 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed in accordance with the EC A.4 and OECD 104 guidelines and complied with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- (2009)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- (2006)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: Effusion method: Isothermal thermogravimetry
Test material
- Reference substance name:
- 3-aminopyrazine-2-carboxylic acid
- EC Number:
- 226-558-7
- EC Name:
- 3-aminopyrazine-2-carboxylic acid
- Cas Number:
- 5424-01-1
- Molecular formula:
- C5H5N3O2
- IUPAC Name:
- 3-aminopyrazine-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Amiloride Compound 5
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 25 °C
- Vapour pressure:
- 6.4 other: E-04 Pa
- Temp.:
- 20 °C
- Vapour pressure:
- 3 other: E-04 Pa
Any other information on results incl. tables
Results of the isothermal TGA analysis
Temperature [°C] |
Weight loss [µg/min] |
νT [g/cm2/h] |
logνT |
logPT |
110 |
6.922 |
8.26 E-04 |
-3.08 |
1.07 |
5.049 |
6.03 E-04 |
-3.22 |
0.93 |
|
120 |
14.74 |
1.76 E-03 |
-2.75 |
1.42 |
12.91 |
1.54 E-03 |
-2.81 |
1.36 |
|
130 |
31.15 |
3.72 E-03 |
-2.43 |
1.76 |
28.85 |
3.44 E-03 |
-2.46 |
1.73 |
|
140 |
63.01 |
7.52 E-03 |
-2.12 |
2.08 |
59.98 |
7.16 E-03 |
-2.15 |
2.06 |
Vapour pressure regression curve: log PT = -5646x1/T + 15.74 (r = 0.994, n = 8).
Log PT 20°C was calculated to be -3.52
Log PT 25°C was calculated to be -3.19
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of Amiloride Compound 5 was determined to be 6.4E-04 Pa at 25°C (3.0E-04 Pa at 20°C) using the isothermal thermogravimetric effusion method (GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950).
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