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EC number: 946-398-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 June 2015 to 05 February 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.5 (Surface Tension)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: ring method
- Key result
- Water solubility:
- 31 mg/L
- Temp.:
- 22 °C
- pH:
- >= 5.4 - <= 7.9
- Remarks on result:
- other: Based on calculation of critical micelle concentration after determination of surface tension for a range of aqueous sample solutions of differing concentration.
- Details on results:
- - Readings, times and temperatures for the sample solutions are shown in Tables 3.16 to 3.23 (attached).
- The concentration (g/L), Log10 of the concentration and mean surface tension values are shown in Table 3.24 (attached).
- The plot of Log10 concentration (g/L) versus surface tension (mN/m) is shown in Figure 3.6 (attached).
- Line 1 was generated from linear regression of four sample solution concentrations for which the surface tension was shown to be concentration dependent.
- Line 2 was generated from linear regression of two sample solution concentrations for which the surface tension was observed to be essentially independent of concentration.
- The intersection of the two lines gave the critical micelle concentration and was calculated by solving two equations where y = -12.6x + 14.4 (Line 1 equation) and y = -1.00x + 32.0 (Line 2 equation).
- The CMC was determined to be 3.1 x 10E-02 g/L.
- Sample solutions at 0.03 and 0.001 g/L were not used in generating the two lines.
- At a concentration of 0.001 g/L the surface tension was only slightly affected and was approaching that of purified water. - Conclusions:
- The critical micelle concentration of the test item was assessed in accordance with EU Method A5. The critical micelle concentration test is designed to measure surface active materials and is not significantly affected by complex mixtures. The critical micelle concentration of the test item was determined to be 3.1 x 10E-02 g/L at 22.0 ± 0.5 °C and this single result is considered to be the definitive solubility limit of the test item in water. The test item is considered to be slightly soluble (0.1-100 mg/L).
- Executive summary:
GUIDELINE
Experimental procedure was based on Method A.5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 115 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
RESULTS
Critical micelle concentration was found to be 3.1 x 10E-02 g/L at 22.0 ± 0.5 °C by determinining the surface tension of a range of aqueous sample solutions of differing concentration.
CONCLUSION The critical micelle concentration test is designed to measure surface active materials and is not significantly affected by complex mixtures. The critical micelle concentration of the test item was determined to be 3.1 x 10E-02 g/L at 22.0 ± 0.5 °C and this single result is considered to be the definitive solubility limit of the test item in water.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 03 June 2015 to 05 February 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 0 g/L
- Temp.:
- 20 °C
- pH:
- >= 6.8 - <= 7
- Remarks on result:
- other: Positive mode
- Water solubility:
- 0.002 g/L
- Temp.:
- 20 °C
- pH:
- >= 6.8 - <= 7
- Remarks on result:
- other: Negative mode
- Details on results:
- PRELIMINARY TEST
- Preliminary estimates of water solubility at 20.0 ± 0.5 °C for the two loading rates are shown in Table 3.9 (below).
DEFINITIVE TEST
- Typical chromatograms for the 10.0 mg/L standard, matrix blank and Sample 1B are attached.
- Mean total peak areas for the standard and sample solutions are shown in Table 3.10 (attached).
- Calibration plots constructed from the standard data and from which the sample concentrations were interpolated are shown in Figures 3.3 and 3.4 (attached).
- Concentration of test item in the sample solutions is shown in Table 3.11 (below). - Conclusions:
- The water solubility of the test item was assessed in accordance with OECD Guideline 105. Water solubility of the test item at 20.0 ± 0.5 °C was determined at a nominal loading rate of 0.01 g/L and found to be 2.73 x 10E-04 g/L (positive mode) and 2.36 x 10E-03 g/L (negative mode). Due to the complexity of the test item, water solubility was loading rate dependent. At higher loading rates it became difficult to remove the excess dispersed test item from solution, which meant a single definitive result was not possible.
- Executive summary:
GUIDELINE
The assessment was carried out by the flask method using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
RESULTS
Water solubility of the test item at 20.0 ± 0.5 °C was determined at a nominal loading rate of 0.01 g/L and found to be 2.73 x 10E-04 g/L (positive mode) and 2.36 x 10E-03 g/L (negative mode).
CONCLUSION
Due to the complexity of the test item, water solubility was loading rate dependent. At higher loading rates it became difficult to remove the excess dispersed test item from solution, which meant a single definitive result was not possible.
Referenceopen allclose all
DISCUSSION
- The citical micelle concentration (CMC) is an important characteristic of a surfactant.
- At low concentrations of surfactant the surface tension of water is only slightly affected but increasing the concentration before reaching the CMC causes the surface tension to change significantly. After reaching the CMC, and above, the surface tension remains relatively constant or changes with a much more gradual slope.
- Below the CMC, the surfactant is considered to be thermodynamically soluble in the water. Above the CMC, the solubility of the surfactant in water has been exceeded and the excess surfactant aggregates to form micelles. These micelles have significantly less effect on the surface tension of a solution and are considered not to be in solution. Thus the water solubility of a surfactant may be expressed in terms of the CMC.
- The CMC test was performed because the test item was a complex mixture containing highly surface active components and it was not possible to obtain a definitive result from the water solubility test. The test used to determine CMC is designed to measure surface active materials and is not significantly affected by complex mixtures. The test also generates a single result, which can be used as a more definitive solubility limit of the test item in water.
Table 3.9 – Preliminary estimates of water solubility |
|||
Nominal Loading Rate (g/L) |
Concentration (g/L) |
pH |
|
Positive mode |
Negative mode |
||
0.1 |
2.29 x 10E-03 |
2.97 x 10E-02 |
8.2 |
1 |
0.158 |
0.485 |
9.1 |
Table 3.11 – Concentration of test item in sample solutions |
|||||
Sample number |
Shaking at 30 °C (hours) |
Equilibration at 20 °C (hours) |
Concentration (g/L) |
Solution pH |
|
Positive mode |
Negative mode |
||||
1 |
24 |
24 |
3.57 x 10E-04 |
2.98 x 10E-03 |
7.0 |
2 |
48 |
24 |
3.17 x 10E-04 |
2.94 x 10E-03 |
7.0 |
3 |
72 |
24 |
1.44 x 10E-04 |
1.15 x 10E-03 |
6.8 |
Overall concentration (positive mode): 2.73 x 10E-04 g/L at 20.0 ± 0.5 °C |
|||||
Overall concentration (negative mode): 2.36 x 10E-03 g/L at 20.0 ± 0.5 °C |
Description of key information
The critical micelle concentration of the test item was assessed in accordance with EU Method A5. The critical micelle concentration test is designed to measure surface active materials and is not significantly affected by complex mixtures. The critical micelle concentration of the test item was determined to be 3.1 x 10E-02 g/L at 22.0 ± 0.5 °C and this single result is considered to be the definitive solubility limit of the test item in water. The test item is considered to be slightly soluble (0.1-100 mg/L).
Key value for chemical safety assessment
- Water solubility:
- 0.031 g/L
- at the temperature of:
- 22 °C
Additional information
No additional data.
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