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EC number: 203-464-4 | CAS number: 107-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16/01/13-14/02/13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- Presumed the method was used due to the volatility of the test substance
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Propiononitrile
- EC Number:
- 203-464-4
- EC Name:
- Propiononitrile
- Cas Number:
- 107-12-0
- Molecular formula:
- C3H5N
- IUPAC Name:
- propanenitrile
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
Date and Quantity Received: 17 Dec 12; 302.8 g (GW)
Physical Description: Clear liquid Storage
Conditions: Room temperature
Purity: Not provided to testing facility
Stability: Not provided to testing facility
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
Preparation of Test Substance Solution (~2 mg/L): Propionitrile (7.0 mg) was added to 3.5 L of mineral medium, and homogenized.
Preparation of Test Substance Solution (~10 mg/L): Propionitrile (35.0 mg) was added to 3.5 L of mineral medium, and homogenized
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Brazos River Valley Sewer Authority
- Laboratory culture: Lot No. Q130016.01
- Preparation of inoculum for exposure: Inoculum was added at the rate of 5 mL/L to the test substance, reference and toxicity reference solutions. - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- ca. 2 mg/L
- Based on:
- test mat.
- Initial conc.:
- ca. 10 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- other: dissolved oxygen
- Details on study design:
- TEST CONDITIONS
- Composition of medium: All solutions were made to 1 L using deionized water. Solution A: 33.40 g Na2HPO4 . 2H2O 8.50 g KH2PO4 21.75 g K2HPO4 0.50 g NH4Cl Solution B: 36.40 g CaCl2 . 2H2O Solution C: 22.50 g MgSO4 . 7H2O Solution D: 0.25 g FeCl3 . 6H2O Eighteen milliliters of each of these prepared stock solutions (A, B, C and D) was added to 18 L of deionized water.
- Test temperature: 22-23°C
- Aeration of dilution water: BOD nutrients were added at the rate of 1 mL /L deionized water. The test medium was aerated for 20 minutes.
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: BOD bottle
- Number of culture flasks/concentration: 10
- Measuring equipment: YSI Model 5100 Dissolved Oxygen Meter
SAMPLING
- Sampling frequency: 7 days
- Sampling method: Two BOD bottles for each solution were removed at each sampling interval (0, 7, 14, 21 and 28 days). The oxygen in each duplicate set of solutions was measured and recorded at each interval
CONTROL AND BLANK SYSTEM
- Inoculum blank: Mineral media (3.5 L) was used as a blank and inoculum was added at the rate of 5 mL/L test media. This was homogenized for 15 minutes.
- Abiotic sterile control: Distilled aniline (7.0 mg) was added to 3.5 L of mineral medium, and homogenized.
- Toxicity control: Distilled aniline (7.0 mg) and 7.0 mg of Propionitrile were added to 3.5 L of mineral medium, and homogenized.
Reference substance
- Reference substance:
- aniline
- Remarks:
- Manufacturer: Sigma Aldrich, Lot: 35196, Expiration: Jul 2016
Results and discussion
- Preliminary study:
- Not applicable
- Test performance:
- absence of data
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 110.1
- Sampling time:
- 28 d
- Remarks on result:
- other: 2 mg/l
- Parameter:
- % degradation (O2 consumption)
- Value:
- -18.5
- Sampling time:
- 7 d
- Remarks on result:
- other: 2 mg/L
- Parameter:
- % degradation (O2 consumption)
- Value:
- 58.2
- Sampling time:
- 14 d
- Remarks on result:
- other: 2 mg/l
- Parameter:
- % degradation (O2 consumption)
- Value:
- 87.4
- Sampling time:
- 21 d
- Remarks on result:
- other: 2 mg/l
- Parameter:
- % degradation (O2 consumption)
- Value:
- -6.5
- Sampling time:
- 7 d
- Remarks on result:
- other: 10 mg/l
- Parameter:
- % degradation (O2 consumption)
- Value:
- 14.5
- Sampling time:
- 14 d
- Remarks on result:
- other: 10 mg/l
- Parameter:
- % degradation (O2 consumption)
- Value:
- 25.1
- Sampling time:
- 21 d
- Remarks on result:
- other: 10 mg/l
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 24
- Sampling time:
- 28 d
- Remarks on result:
- other: 10 mg/l
- Details on results:
- The test is based on a theoretical oxygen demand of 2.543 mg O2/mg Propionitrile. Since a sealed jar test begins with 9 mg/L O2 and at 10 mg/L of propionitrile, the oxygen demand will be 10 mg/L x 2.543 mgO2/mg = 25.43 mg/L O2. This test at theis concnetration should have not been performed.
BOD5 / COD results
BOD5 / COD
- Key result
- Parameter:
- COD
- Value:
- 2.543 other: mgO2/mg
- Results with reference substance:
- ThOD (mgO2/mg) 2.405;
Day 7 Net D.O. Depletion (mg/L) 2.545; % Degradation 52.9%
Day 14 Net D.O. Depletion (mg/L) 1.185; % Degradation 24.6%
Day 21 Net D.O. Depletion (mg/L) 3.435; % Degradation 71.4%
Day 28 Net D.O. Depletion (mg/L) 2.410; % Degradation 50.1%
Any other information on results incl. tables
Table 1. Concentration validation
Test Sample |
Concentration (mg/L) |
BOD media |
Not Detected |
2 mg/L |
<1 |
10 mg/L |
21.0620 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- the test is valid only at the concentration of 2mg/l. At 10 mg/l the level of oxygen is below the limit.
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Remarks:
- at 2 mg/l
- Conclusions:
- For test substance, Propionitrile, at 2 mg/L, values of -18.5%, 58.2%, 87.4% and 110.1% biodegradation was obtained on Days 7, 14, 21 and 28; therefore, the test substance is considered readily biodegradable at 2 mg/L.
The test is based on a theoretical oxygen demand of 2.543 mg O2/mg Propionitrile. Since a sealed jar test begins with 9 mg/L O2 and at 10 mg/L of propionitrile, the oxygen demand will be 10 mg/L x 2.543 mgO2/mg = 25.43 mg/L O2. This test at theis concnetration should have not been performed. - Executive summary:
A study was performed meausure the biodegrability of Propiopionitrile following the OECD guidelines 301D. The study was conducted following GLP standard and it was considered reliable (Klimish 2) with restrictions. At 2 mg/l Propionitrile was readily biodegradable, with 58.2%, 87.4% and 110.1% biodegradation obtained on Days 14, 21 and 28 respectevely.
At 10 mg/l the level of dissolved oxygen fall below 0.5 mg/l after 21 days. limting so the activity of the inoculum. Furthermore, The test is based on a theoretical oxygen demand of 2.543 mg O2/mg Propionitrile. Since a sealed jar test begins with 9 mg/L O2 and at 10 mg/L of propionitrile, the oxygen demand will be 10 mg/L x 2.543 mgO2/mg = 25.43 mg/L O2. This test at theis concnetration should have not been performed.
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