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Diss Factsheets
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EC number: 907-132-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- prior to 1946
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparison of the Chronic Toxicity of Triethylene Glycol that of Diethylene Glycol
- Author:
- Fitzhugh, O.G. and Nelson, A.A.
- Year:
- 1 946
- Bibliographic source:
- J Ind Hyg Toxicol. 1946 Mar; 28:40-3.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Two year bioassay comparing the toxicity of triethylene glycol to diethylene glycol (data not presented for diethylene glycol).
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
- Test material form:
- not specified
- Details on test material:
- triethylene glycol was used. No further information supplied in paper.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male rats from their own colony (Dept. of Pharmacology, Food and Drug Administration, Washington, D.C.) of Osborne-Mendel strain were used. They were selected at random with respect to litter mates. Three rats were chosen from each of 7 litters and assigned to different diets as required for balanced incomplete blocks of 3 with 7 treatments, where the blocks correspond to litters and the treatments to diets. The design was replicated as a whole 4 times, giving a total of 84 rats. Three groups of rats were placed on 1, 2 and 4 percent diethylene glycol and three other groups were placed on 1, 2 and 4 percent triethylene glycol. the seventh ration was the control diet without added glycol.
Ground commercial rat biscuits with 1 percent added cod liver oil were used as a basic diet. the rats were kept in individual cages in a room with the temperature and humidity controlled for the duration of the experiment, and they were griven free access to their respective diets and water.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on exposure:
- Groups of rats were fed 1, 2 or 4% triethylene glycol in the diet
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data.
- Duration of treatment / exposure:
- 2 years
- Frequency of treatment:
- continuous in feed
- Post exposure period:
- No data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1, 2 or 4%
Basis:
nominal in diet
- No. of animals per sex per dose:
- 12 males/dose level
- Control animals:
- yes, plain diet
- Details on study design:
- Three groups of rats were placed on 1, 2 and 4 percent diethylene glycol (data not presented here) and three other groups were placed on 1, 2 and 4 percent triethylene glycol. the seventh ration was the control diet without added glycol. The weights of individual animals and their food consumption were determined at weekly intervals.
- Positive control:
- No data.
Examinations
- Observations and examinations performed and frequency:
- The weights of individual animals and their food consumption were determined at weekly intervals.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- There was no effect on mortality of rats fed 1, 2 or 4% triethylene glycol in the diet for 2 years.
When the data for the weekly food consumption of each group during the first 26 weeks and the second 26 weeks of the experiment were analyzed, the differences between the control and experimental animals were not statistically significant.
Pathological Changes. All of the 84 rats used in these experiments (NOTE: Some rats were fed diethylene glycol which is not included here but can not be separated out in text) were examined for gross visceral changes, and 48 of the 84 were sectioned microscopically. Routine sections included lung, heart, liver, spleen, pancreas, stomach, small intestine, colon, kidney, adrenal, testis and bladder tumors. Bladder, prostate, seminal vesicle, leg bones, bone marrow, voluntary muscle, thyroid and lymph node were sectioned in some animals.
In rats fed triethylene glycol pathological changes were essentially absent. In the rats fed triethylene glycol and in the untreated controls there were no stones or tumors in the urinary tracts. Liver, lung, heart, spleen, pancreas, stomach, small intestine, colon, adrenal, testis, prostate, seminal vesicles, bone, bone marrow, voluntary muscle, lymph node and thyroid showed either no changes attributable to triethylene glycol, or else changes so slight or infrequent that they were of questionable significance. - Relevance of carcinogenic effects / potential:
- Triethylene glycol produced no toxic effect, including cancer, at doses as high as 4% in the diet.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 4 other: percent in the diet
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No effects were noted in male rats fed 4% triethylene glycol in the diet.
- Remarks on result:
- other: Effect type: toxicity
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Conclusions:
- Triethylene glycol produced no toxic effect at doses as high as 4% in the diet.
- Executive summary:
In a 1946 era study, groups of 12 male rats were fed 0, 1, 2 or 4 percent triethylene glycol in the diet for 2 years. In this study, triethylene glycol produced no toxic effect at doses as high as 4% in the diet.
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