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Diss Factsheets
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EC number: 206-144-2 | CAS number: 303-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data on clomipramine
Value: 31.5 mg/L (Mass concentration)
Original value: 100 microM (Molar concentration)
Class: Oligochaeta
Duration: 15 min
Effect: Physiology
Effect %: ca. 19
Endpoint: LOEC
Family: Lumbriculus (aquatic oligochaete worm)
Infrakingdom: Protostomia
Measurment: heart rate
Data on clomipramine hydrochloride (similar substance)
No experimental data for aquatic toxicity were found for clomipramine hydrochloride; therefore, modelled data were used to estimate the potential for aquatic toxicity. Table that contains the predicted ecotoxicity values that were considered reliable and were used in the QSAR weight of evidence approach for aquatic toxicity (Environment Canada 2007b) is provided in the full documentation.
A range of aquatic toxicity predictions were obtained from the various QSAR models considered. The results suggest that clomipramine will have moderate to high toxicity to aquatic species and that the ionized form (corresponding to a measured log Kow of 3.32), which is likely to predominate at environmental pH 6-9, will be less toxic than the neutral compound. The ionized form of clomipramine is predicted to cause acute effects to aquatic species at concentrations ranging from <1 mg/L to about 10 mg/L. Based on this model evidence, clomipramine hydrochloride has the potential to be acutely toxic to aquatic organisms at relatively low concentrations (acute LC/EC50 values < 1.0 mg/L).
Overall, the substance is classified as Aquatic Acute 1 H400.
Biodegradation
In the absence of measured environmental biodegradation data, such as ready biodegradation data, and in light of the unanimity of the model predictions particularly relating to ultimate degradation, clomipramine hydrochloride will be considered to meet the persistence criteria (i.e., half-life in water is 182 days).
While the neutral form of clomipramine is predicted to have high bioaccumulation potential, the ionized form most likely to predominate in the environment has a low potential to bioaccumulate.
The substance is classified as Aquatic Chronic 1 H410.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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