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EC number: 210-894-6 | CAS number: 625-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy-, and N-butoxyacetic acids in the rat
- Author:
- Foster P M D, Lloyd S C, Blackbum D M
- Year:
- 1 987
- Bibliographic source:
- Toxicology, 43: 17-30.
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Details on study design:
- Methoxyacetic acid was administered to male rats by stomach tube as single oral doses of 118, 296 or 592 mg/kg bw. Testicular weight and morphology were monitored over a 14-day period post-treatment. Six animals/group, including a control group, were killed after 1, 2, 4 and 14 days and the testes, epididymides, seminal vesicles, prostate and liver were histopathologically examined.
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
In the animals of the lowest dose group, minimal damage (pyknosis, condensing of the cell nuclei) occurred in the spermatocytes at the early pachytene or diplotene stages, as well as damage to the secondary spermatocytes. After 14 days, mature spermatids were also affected.
The high dose led to degenerative changes and loss of secondary spermatocytes, spermatids and spermatocytes in the zygotene, pachytene, diplotene and diakinesis stages. An increase in the number of spermatocytes at the pachytene stage was observed 14 days after exposure. An increased number of immature and abnormal cells was found in the epididymides. No findings were noticed in the seminal vesicles, prostate or liver on histological examination.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Methoxyacetic acid was administered by gavage to rats as single oral doses of 118, 296 or 592 mg/kg bw. Testicular weight and morphology were monitored over a 14-day period post-treatment. Dosage with Methoxyacetic acid resulted in a significant decrease in testicular weight. Histological examination of the testes from treated animals indicated that Methoxyacetic acid at all doses produced damage specific to spermatocytes undergoing meiotic maturation and division within 24 h of treatment.
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