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Diss Factsheets
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EC number: 204-977-6 | CAS number: 130-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No methods have been provided in the literature.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 190 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50= 190 mg/ kg bw
Reference
Male white rats (168 to 185 g) were given the substance orally as an oily solution at doses of 100, 150, 200, 250 and 300 mg/kg body weight. The LD50 was 190 (160 to 220) mg/kg body weight. In all cases postmortems revealed congestion of the internal organs, necrosis and haemorrhages of the gastric mucosa, blurring of the border between the cortex and the medulla of the kidney and in some cases "nutmeg liver" and the accumulation of gas in the small and large intestine.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 190 mg/kg bw
- Quality of whole database:
- 2
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- performed in 1981
- GLP compliance:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Duration of exposure:
- 4 h
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- LC 50=0.046 mg/l
Reference
The acute inhalation toxicity of 95.8% pure 1,4 -naphthoquinone was studied in accordance with OECD guideline No. 403. Groups of 5 male and 5 female Sprague Dawley rats (initial weight ca. 200 g) were exposed to 1,4 -naphthoquinone as a solid aerosol by inhalation at analytically determined concentrations of 0.065, 0.036 and 0.021 mg/l air for 4 hours (whole body exposure) with an observation period of 14 days The mean aerodvnamic particle diameter was 3.8 to 4.2 µm anel the respirable fraction <6 µm) was between 64.4 and 69.8%. During exposure, signs of irritation of the eyes and respiratory tract, which continued into the observation period, were seen in all concentration groups. Clouding of the cornea developed in 5/17 surviving animals in the intermediat and low concentration groups. Feed and water consumption was decreased for up to 7 and 5 days after exposure, respectively. Body weight declined for up to 5 days after exposure and the weight of the surviving rats did not reach that of the control animals again by the end of the observation period, except in the low concentration group. Post-mortems revealed congestion of the lungs, which were mottled in places, and histological examination showed vacuolisation and necrotic foci in the liver cells. The LC50 values were 0.039 mg/l in males, 0.053 mg/l in females and 0.046 mg/l for both sexes combined.
ormal respiration, reduction in food consumption and body weight, pale and mottled lungs, microscopic changes in lungs
(congestion), livers (hepatocyte vacuolisation, necrosis, congestion/dilatation) and kidneys (tubular basophilia, dilatation of tubular lumen).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 46 mg/m³
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.