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Diss Factsheets
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EC number: 278-169-7 | CAS number: 75277-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Reliable experimental data on the short-term toxicity of the target substance towards aquatic invertebrates is available. The information requirements for short-term toxicity to fish, toxicity to aquatic algae and toxicity to microorganisms was covered by applying a read-across approach in accordance with Regulation (EC) No 1907/2006 (REACH) Annex XI, section 1.5 (a detailed read-across justification is attached to IUCLID section 13). Target and source substances share the same chemical structures and functional groups and have the same type of physico-chemical, toxicological and ecotoxicological effects based on common underlying mechanisms.
The non-toxicity of the read-across source and target substance, respectively, to aquatic species of three trophic levels was demonstrated in reliable guideline studies. The EC50 for aquatic invertebrates and green algae were determined to be > 100 mg/L and the NOEC for green algae was ≥ 100 mg/L. The LC50 for fish was > 100 mg/L. Based on these results the target substance is neither classified for short-term (acute) aquatic toxicity, nor for long-term (chronic) aquatic toxicity in accordance with the criteria laid down in Regulation (EC) No 1272/2008 (CLP Regulation), as last amended for the seventeenth time in Regulation (EU) 2021/849. Moreover, in compliance with the criteria of the same regulation, the target substance is not classified for physico-chemical or human health hazards. The substance is not readily biodegradable and has no potential for bioaccumulation. The log Pow of the test item was determined to be < -3.88 at 20 °C (reference 4.7-1). The target substance is hence not considered PBT or vPvB (please refer to PBT/vPvB assessment in IUCLID section 2.3). It is thus concluded, that no toxic effect to the environment or man via the environment has to be expected. Therefore, in compliance with REACH Article 14 (4), an exposure assesment is not necessary and PNECs were not derived.
Conclusion on classification
As the substance poses no hazard to aquatic organisms, and consequently not to the various environmental compartments (freshwater, marine water, STP, sediment (fresh and marine water), soil, air, predators), no classification is warranted.
Classification related information
Biodegradation: not readily biodegradable: -2 % (based on oxygen uptake after 28 days OECD 301 D, read-across)
Hydrolysis: t1/2 > 1 year at 25 °C and pH 4, 7 and 9 (read-across)
Partition coefficient: log Kow = -3.88 at 20 °C
Aquatic acute toxicity
96 h, LC50 (Danio rerio): > 100 mg/L (nominal concentration, read-across)
48 h, EC50 (Daphnia magna): > 100 mg/L (nominal concentration)
72 h, ErC50 (Pseudokirchneriella subcapitata): > 100 mg/L (nominal concentration, read-across)
Aquatic chronic toxicity
72 h NOEC (Pseudokirchneriella subcapitata): ≥ 100 mg/L (nominal concentration, read-across)
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. The test substance was found to be not readily biodegradable under the test conditions. In all aquatic tests the test item showed no toxic effect on the tested species. The determined EC50 for Daphnia magna and green algae were > 100 mg/L and the NOEC for green algae was ≥ 100 mg/L. The LC50 for fish was > 100 mg/L. Based on these results, the substance is neither classified as short-term (acute) aquatic toxicity nor classified as long-term (chronic) aquatic toxicity according to Regulation (EC) No 1272/2008 (CLP), as amended for the seventeenth time in Regulation (EU) 2021/849.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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