3-methylpyridine

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vivo (non-LLNA)

Remarks:

existing in vivo data which predates adoption of REACH and its supplemental regulations

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Information comes from a submission of a collection of acute toxicity data to the U.S. EPA, and provides little documentation. The studies use older protocols using guinea pigs; they predate the adoption of the REACH legislation and the development of the LLNA and in vitro methods.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day.

GLP compliance:

no

Type of study:

other: guinea pig

Justification for non-LLNA method:

The studies use older protocols using guinea pigs; they predate the adoption of the REACH legislation and the development of the LLNA and in vitro methods.

Test material

Test material information

Constituent 1

Reference substance name:

Pyridine

EC Number:

203-809-9

EC Name:

Pyridine

Cas Number:

110-86-1

Molecular formula:

C5H5N

IUPAC Name:

pyridine

Details on test material:

no data

In vivo test system

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Results and discussion

In vivo (non-LLNA)

Results

Key result

Reading:

1st reading

Hours after challenge:

24

Group:

test chemical

No. with + reactions:

0

Total no. in group:

3

Remarks on result:

no indication of skin sensitisation

Remarks:

Assume 0 sensitised of at least 3 animals at 24 h reading

Any other information on results incl. tables

Not sensitising in guinea pigs.

As dermal irritation and toxicity of pyridine in guinea pigs was well studied and reported, it is anticipated that the dosage was appropriately chosen for this sensitisation study.

Applicant's summary and conclusion

Interpretation of results:

not sensitising

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The dermal sensitisation properties of the category substance pyridine were studied in the guinea pig, and pyridine was found to be a non-sensitiser. This read-across approach is valid for the purposes of classification and labelling, and for risk assessment. Additionally, appropriate risk management measures for a corrosive substance are protective of workers.