Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-840-3 | CAS number: 155-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, comparable to guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
- Reference Type:
- publication
- Title:
- Disposition of 2-meraptobenzothiazole and 2-mercaptobenzothiazole disulfide in rats dosed intravenously, orally, and topically and in guinea pigs dosed topically
- Author:
- El Dareer, S., M.; et al.
- Year:
- 1 989
- Bibliographic source:
- Journal of Toxicology and Environmental Health, 27, 65-84
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 427 (Skin Absorption: In Vivo Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- MBT purity: 98%
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C MBT
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: tetrahydrofuran
- Duration of exposure:
- up to 96 h
- Doses:
- 0.0361 mg (0.00501 mCi)/animal
- No. of animals per group:
- 4 per dose and sex
- Control animals:
- no
Results and discussion
Percutaneous absorptionopen allclose all
- Dose:
- 0.0361 mg (0.00501 mCi)/animal
- Parameter:
- percentage
- Absorption:
- 16.1 %
- Remarks on result:
- other: 96 h
- Remarks:
- male rat
- Dose:
- 0.0361 mg (0.00501 mCi)/animal
- Parameter:
- percentage
- Absorption:
- 17.5 %
- Remarks on result:
- other: 96 h
- Remarks:
- female rats
Any other information on results incl. tables
Animal morbidity and mortality were also checked daily during the experiment. No mortality and no evidence of morbidity were observed.
By washing of the site of application, more radioactivity from [14C] MBT and [14C] MBTS was removed from guinea pigs than from rats. Amounts of [14C] MBT removed from the site of application by washing were 6.07, 9.01, and 38.2 % of the dose for male rats, female rats, and guinea pigs, respectively.
After washing of the skin radioactivity from [14C] MBT remaining at the site of application was 61.5, 51.6, and
15.2% of the dose for male rats, female rats, and guinea pigs, respectively.
Guinea pigs absorbed more radioactivity from [14C] MBT and [14C] MBTS than rats; and, for both species, absorption of [14C] MBT was more extensive than that for [14C] MBTS. In 96 hr, 16.1, 17.5, and 38.4% of the dose of [14C] MBT was absorbed by male rats, female rats, and guinea pigs, respectively. Rats and guinea pigs absorbed about 2.5-fold more [14C] MBT than [14C] MBTS.
For male and female rats dosed topically with [14C] MBT, there were no values for the same type of sample that did not have overlapping standard deviations.
For male rats, female rats, and guinea pigs dosed with [14C] MBT, the concentration
of radioactivity in whole blood relative to that in plasma was 12.7-, 12.9-, and 7.3-fold greater, respectively
For both [14C] MBT and [14C] MBTS, urine was the primary route for excretion of absorbed radioactivity. Of the absorbed dose of [14C] MBT, the amounts excreted in urine were 74% by male rats, 77% by female rats, and 87% by guinea pigs.
Similarly for [14C] MBTS, 54% was excreted in urine by male rats, 68% by female rats, and 73% by guinea pigs. For both compounds, the percentage of the dose excreted in the urine of guinea pigs was 2.1-2.8-fold that for rats, suggesting that in these species, MBT and MBTS follow the same excretory pattern.
In contrast, more radioactivity (2-3-fold) from [14C] MBT was excreted in the feces by rats than by guinea pigs. This route of excretion was minor, however accounting for less than 7% of the absorbed dose.
Total recovery of radioactivity ranged from 81.9 to 94.4% of the dose of [14C] MBT and from 76.8 to 88.7% of the dose of [14C] MBTS.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.