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Diss Factsheets
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EC number: 910-356-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Remarks:
- summary of various observations in humans after ingestion of copper compounds
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report COPPER, COPPER II SULPHATE PENTAHYDRATE, COPPER(I)OXIDE, COPPER(II)OXIDE, DICOPPER CHLORIDE TRIHYDROXIDE CAS No: 7440-50-8, 7758-99-8, 1317-39-1, 1317–38–0, 1332-65-6 - VOLUNTARY RISK ASSESSMENT
- Author:
- European Copper Institute
- Year:
- 2 007
- Bibliographic source:
- https://echa.europa.eu/de/copper-voluntary-risk-assessment-reports
Materials and methods
- Study type:
- other: summary of various observations in humans after ingestion of copper compounds
- Endpoint addressed:
- acute toxicity: oral
Test material
- Reference substance name:
- Copper sulphate
- EC Number:
- 231-847-6
- EC Name:
- Copper sulphate
- Cas Number:
- 7758-98-7
- Molecular formula:
- CuSO4
- IUPAC Name:
- Copper sulphate
- Test material form:
- solid
Constituent 1
Results and discussion
Any other information on results incl. tables
The most reliable studies for the determination of a NOAEL for adults are two well-controlled, internationally diverse volunteer studies in which copper (as copper sulphate) was administered as a single dose in drinking water (Arayaet al,2001; Arayaet al, 2003). Both studies reported a concentration-related increase in gastrointestinal symptoms associated with single oral exposure to copper in drinking water, the earliest and most frequently reported symptom being nausea. In both of these studies, the NOAEL for gastrointestinal symptoms in adults was a concentration of 4 mg/litre copper in drinking water (0.8 mg Cu); the LOAEL was 6 mg/litre copper in drinking water (1.2 mg Cu). These values were the same for a female study population or a male and female combined study population.
Ingestion of large amounts of copper sulphate, as in cases of self-poisoning, is associated with severe hepatotoxicity, nephrotoxicity and gastrointestinal effects, in several cases resulting in fatalities. Such reports of copper sulphate ingestion do not enable a NOAEL to be derived.
Effects generally observed include e.g. nausea, abdominal pain and vomiting.
With regard to inhalation exposure, although copper has been implicated in the aetiology of metal fume fever, a review of the available literature suggests there is insufficient evidence to support this claim (see also RAC- Opinion proposing harmonised classification and lebelling at EU Level of Copper (II) oxide; 2014).
Applicant's summary and conclusion
- Conclusions:
- The most reliable and relevant dose-response data for acute toxicity come from two well-controlled, oral exposure studies conducted in human volunteers (Araya et al, 2001; Araya et al, 2003). In both of these studies, a concentration-related increase in gastrointestinal symptoms was associated with single oral exposure to copper in drinking water. The NOAEL for gastrointestinal symptoms in adults was 4 mg Cu/litre drinking water (0.8 mg Cu) and the LOAEL was 6 mg/litre (1.2 mg Cu).
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