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EC number: 233-701-7 | CAS number: 10319-14-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 (oral) ca 4788 mg/kg bw active ingredient
Key value for chemical safety assessment
Additional information
The potential of the substance for acute toxicity following oral administration was tested in male and female rats of the CFY strain. 5 animals per sex per dose were tested at doses of 4000, 6400, 10000 and 16000 mg/kg bw and observed for 14 days.
Sign of reaction to treatment observed shortly after dosing, included lethargy, pilo-erection, abnormal body carriage (hunched posture), abnormal gait (waddling), ptosis and diarrhoea. These signs were accompanied by increased salivation and decreased respiratory rate amongst rats treated at 6.4 g/kg and above and by diuresis amongst rats at 10 to 16 g/kg.
Yellow colouration of the urine and faeces was noted for rats trated at 16 g/kg.
Death occured among rats treated at 4.0, 10 or 16 g/kg within 3 to 29 hours of dosing. Autopsy revealed congestion and haemorrhage of the lungs and pallor of the liver, spleen and kidneys.
Based on the active ingredient content, namely 4788 mg/kg bw, the test substance is not classified as acutely toxic by oral exposure route.
Justification for classification or non-classification
The CLP Regulation (EC 1272/2008), Annex I, Part 3, Table 3.1.1 gives the following criteria for acute oral toxicity: "Category 4: 300 < ATE ≤ 2 000," where ATE is acute toxicity estimates in mg/kg bodyweight.
LD50 of the test substance is considered > 4.000 mg/kg bw, which is outside the above criteria.
Therefore, the test substance is not acutely toxic by the oral exposure route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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