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Diss Factsheets
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EC number: 249-828-6 | CAS number: 29761-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- In Vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 14, 1980 - July 21, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study similar to OECD Guideline 405. QA. Environmental conditions not reported. Acceptable basic data.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 9 rabbits; exposure time
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isodecyl diphenyl phosphate
- EC Number:
- 249-828-6
- EC Name:
- Isodecyl diphenyl phosphate
- Cas Number:
- 29761-21-5
- Molecular formula:
- C22H31O4P
- IUPAC Name:
- isodecyl diphenyl phosphate
- Reference substance name:
- 180-415 (C9889-147)
- IUPAC Name:
- 180-415 (C9889-147)
- Details on test material:
- - Name of test material (as cited in study report): 180-415
- Physical state: liquid
- Analytical purity: no data
- Lot/batch No.: no data
- Stability under test conditions: no data
- Storage condition of test material: room temperature
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry, Lumberton, Texas, USA
- Age at study initiation: young adult
- Weight at study initiation: no data
- Housing: individually, in suspended wire bottom galvanize steel gages
- Diet (e.g. ad libitum): Purina rabbit chow, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: approx. one week
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): undiluted (100%) - Duration of treatment / exposure:
- 6 rabbits: 7 days (unwashed)
3 rabbits: 30 seconds (washed) - Observation period (in vivo):
- 1, 24, 48, and 72 hours, and at 4 and 7 days after treatment
- Number of animals or in vitro replicates:
- 9 (6 males and 3 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 3 of the 9 treated rabbits washed with room temperature deionised water for 1 minute
- Time after start of exposure: 30 seconds after treatment
SCORING SYSTEM: Numerical according to guidelines described by Draize (1965) (corneal, iridic and conjunctival irritation (redness/chemosis/discharge)).
TOOL USED TO ASSESS SCORE: fluorescein: observations with fluorescein staining were made at 1 and 24 hours after the application of the test substance and until there was no staining for 3 consecutive observations.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 9 rabbits
- Time point:
- other: 24, 48,and 72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Remarks on result:
- other: washed and unwashed eyes
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24, 48, and 72 hours
- Score:
- ca. 0.16
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: unwashes eyes
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24, 48, and 72 hours
- Score:
- ca. 0.66
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: unwashed eyes
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24, 48, and 72 hours
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: washes eyes
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24, 48, and 72 hours
- Score:
- ca. 0.16
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: unwashed eyeys
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24, 48, and 72 hours
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: washed eyes
- Other effects:
- None
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the mean scoring results (all < 1.00) and according to the criteria outlined in 67/548/EEC and 1272/2008/EC (CLP/EU-GHS), 180-415 does not have to be classified and has no obligatory labelling requirement for eye irritation.
- Executive summary:
This eye irritation test, comparable to OECD Guideline 405, consists of a single instillation of 0.1.ml of the undiluted test material (180-415) into the conjunctival sac of the left eye of each of 9 rabbits. The treated eye was washed with water 30 seconds after exposure in 3 rabbits and the eyes were left unwashed in the remaining 6 rabbits. The untreated eye of each animal served as a negative control. The cornea, the iris, and conjunctivae were observed at 1, 24, 48, and 72 hours, and at 4 and 7 days after treatment. Observations with fluorescein staining were made at 1 and 24 hours after the application of the test substance and until there was no staining for 3 consecutive observations. The guidelines described by Draize (1965) were used to assign numerical scores to the observed effects and to develop a weighted total score for each animal for each day of observations. Based on the mean scoring results (all < 1.00) and according to the criteria outlined in 67/548/EEC and 1272/2008/EC (CLP/EU-GHS), 180-415 does not have to be classified and has no obligatory labelling requirement for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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