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EC number: 245-026-5 | CAS number: 22483-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,2-dimethoxyethylamine
- EC Number:
- 245-026-5
- EC Name:
- 2,2-dimethoxyethylamine
- Cas Number:
- 22483-09-6
- Molecular formula:
- C4H11NO2
- IUPAC Name:
- 2,2-dimethoxyethanamine
- Reference substance name:
- HF 88035
- IUPAC Name:
- HF 88035
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédo (69210 L'Arbresle, France)
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 163 ± 5 g (males) and 141 ± 4 g (females)
- Fasting period before study: yes (18 hours before the administration of the substance)
- Housing: groups of 5 animals of the same sex, in polycarbonate cages (48 x 27 x 20 cm)
- Diet: certified pellet diet "Rats et Souris entretien référence A04 C", ad libitum
- Water: free access to tap water filtered by 0.22 micron filter membrane
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3 °C
- Humidity: 50 ± 30 %
- Air changes: non recycled, filtered by absolute filters
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: from 12 September 1989 to 26 September 1989 (from treatment to the end of the observation period)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: -
MAXIMUM DOSE VOLUME APPLIED: 10 mg/kg - Doses:
- 2000, 2700, 3700, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> clinical signs: frequently after administration and at least once a day for 14 days.
> Mortality: frequently after administration and at least twice a day for 14 days.
> Body weight: just before administration, and then on days 5, 8 and 15
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 700 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The mortality rates were 0%, 0%, 40% and 100% respectively on doses of 2000, 2700, 3700 and 5000 mg/kg bw. The death occurred within hours of treatment.
- Clinical signs:
- Included in the clinical signs after administration of the test substance was a slight or severe decrease in spontaneous activity both in males and females. This decrease in activity was functional to the dose administrated and had disappeared after 2 hours at 2000 mg/kg, after 48 hours at 2700 mg/kg and on day 5 at 3700 mg/kg.
- Body weight:
- Bodyweight gain of the treated survinving animals slowed down between day 1 and day 5 depending on the dose administrated. The bodyweight gain returned to normal thereafter.
- Gross pathology:
- Necropsies performed on animals found dead during the study or sacrificed at the end of the study showed no visible macroscopic anomalies.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of dimethoxy-2,2 ethylamine was higher than 2000 mg/kg bw (no mortality), but lower than 5000 mg/kg bw (100% mortality). LD50 is probably around 3700 mg/kg bw at which the mortality was 40%).
- Executive summary:
Dimethoxy-2,2 ethylamine was tested for acute oral toxicity in male and female Sprague-Dawley rats by gavage according to EU testing guideline B.1 and Good Laboratory Practice.
The LD50 of dimethoxy-2,2 ethylamine was higher than 2000 mg/kg bw (no mortality), but lower than 5000 mg/kg bw (100% mortality). LD50 is probably around 3700 mg/kg bw at which the mortality was 40%).
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